Weight Gain Clinical Trial
Official title:
Effects of Insulin Detemir and NPH Insulin on Renal Handling of Sodium, Fluid Retention and Weight in Type 2 Diabetic Patients
Hypothesis: Changing type 2 patients treatment from Insulin Insulatard to Insulin Detemir will increase their excretion of sodium in the urine and thereby decrease their extracellular volume and body weight. 24 patients are divided into 2 groups and their insulin treatment is shifted while their body composition, sodium excretion, weight and extracellular volume is monitored.
Type 2 diabetic patients experience weight gain when receiving insulin treatment. There has
been reports that the weight gain is less or absent when patients are treated with Insulin
Detemir. Patients with diabetes have increased total body sodium and increased extracellular
volume. We hypothesize that part of the weight gain seen is due to increase in extracellular
volume and that the lesser weight gain seen in patients treated with Detemir is due to an
lesser increase in extracellular volume. We believe that the cause of this difference is the
different pharmacokinetic properties of insulin Detemir. Insulin Detemir i protein bound and
is therefore not excreted in the kidneys. This may cause less sodium reabsorption, than with
other insulins, and therefore less increase in extracellular volume.
We test this hypothesis by examining urinary sodium excretion, extracellular volume by GFR
measurements, Body composition by DEXA scan, body weight, and 24 hour blood pressure.In
patients that are changed from Insulin Insulatard to Insulin Detemir and back.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03249896 -
Web/Smartphone-based Lifestyle Coaching Program in Pregnant Women With Gestational Diabetes
|
N/A | |
| Recruiting |
NCT04043520 -
Bioenergetic Effects of Aging and Menopause (BEAM)
|
Phase 4 | |
| Completed |
NCT05508750 -
Growth and Safety Clinical Trial on a New Infant Formula
|
N/A | |
| Not yet recruiting |
NCT03225456 -
Oxytocin and Eating
|
Phase 2 | |
| Completed |
NCT02227043 -
Study Of Weight Development Over Time
|
N/A | |
| Not yet recruiting |
NCT01916603 -
Diet, Physical Activity and Breastfeeding Intervention on Maternal Nutrition, Offspring Growth and Development
|
N/A | |
| Completed |
NCT01958307 -
Healthy Living in Pregnancy
|
N/A | |
| Completed |
NCT01693666 -
Lifestyle Intervention Forever: Healthy Weight for Pregnancy and Birth (Pilot Study)
|
N/A | |
| Completed |
NCT01461824 -
Drug Exposure and Depot Medroxyprogesterone Acetate (DMPA) in Adolescent Subjects
|
Phase 3 | |
| Terminated |
NCT00759993 -
Chromium Piccolinate in the Prevention of Weight Gain Induced by Serotonergic Medications Initiated on Psychiatric Inpatient Units.
|
Phase 2 | |
| Completed |
NCT00634530 -
Impact of a Nutritional Intervention Program for Weight Control During Pregnancy
|
N/A | |
| Completed |
NCT00995462 -
Prevention of Weight Gain in University Students
|
N/A | |
| Completed |
NCT00122213 -
A Physical Activity and Diet Program to Prevent Accumulation of Abdominal Fat Mass in Recently Retired Men and Women
|
Phase 2 | |
| Completed |
NCT00306449 -
Prevention of Weight Gain in Young Adults
|
N/A | |
| Completed |
NCT03996551 -
ExeRTiOn2- The Weight Gain Prevention Exercise in Renal Transplant Online Study
|
N/A | |
| Recruiting |
NCT03675464 -
Study of Human Adipose Tissue (LOSHAT)
|
||
| Completed |
NCT04282655 -
Effect of Milk Warming on the Very Low Birth Weight Infant
|
N/A | |
| Recruiting |
NCT05992688 -
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
|
N/A | |
| Completed |
NCT04069351 -
Body Composition Changes During Overfeeding Plus Resistance Training
|
N/A | |
| Completed |
NCT00687115 -
Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting
|
Phase 2 |