Effect of High Flow Oxygen Therapy in Spontaneous Breathing Trial on Weaning in Mechanical Ventilated Patients — HOST  

Mechanical Ventilation Clinical Trial

Official title: A Randomized Trial of High Flow Oxygen Therapy in Spontaneous Breathing Trial on Weaning in Mechanical Ventilated Patients.

Status Recruiting

Clinical Trial Summary

This clinical trial is aimed to show a spontaneous breathing trial using high flow oxygen therapy may lower weaning failure rate and reintubation rate than using T-piece.

Clinical Trial Description

We project to test the effect of high flow oxygen therapy in spontaneous breathing trial on weaning in mechanical ventilated patients. Patients will be randomly assigned to undergo a spontaneous breathing trial in one of two ways: with a T-piece therapy or with high flow oxygen therapy. Primary end-points are rate of weaning failure and rate of reintubation within 48 hr of extubation. Weaning failure is defined as failed to spontaneous breathing trial or reintubation within 48 hr of extubation. Secondary end-points are ICU mortality, in-hospital mortality, ICU length of stay, time to reintubation after extubation. Study sample was calculated to detect ability of high flow oxygen therapy to reduce weaning failure from 42 to 15 percent, at two-tailed alpha error of 5% and power of 85% and 98 patients are needed in each arm. ;

Related Conditions & MeSH terms

• Extubation
• Mechanical Ventilation
• Respiratory Aspiration
• Weaning

• NCT number: NCT03929328
• Study type: Interventional
• Source: Seoul National University Hospital
• Contact: Sang-Min Lee, MD
• Phone: 82-02-2072-0833
• Email: sangmin2@snu.ac.kr
• Status: Recruiting
• Phase: N/A
• Start date: June 17, 2019
• Completion date: December 31, 2021