Exploration of Mechanisms for Weaning Failure

Status Not yet recruiting

Clinical Trial Summary

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT). The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .

Clinical Trial Description

This observational study mainly include participants who had invasive mechanical ventilation for ≥48 h and are assessed to be ready for the SBT trial.The SBT approach is based on the low-level pressure support mode. Prior to the SBT trial, baseline demographic and physiologic data of the participants will be collected, and the participants will be divided into two groups based on the results of the SBT trial: successful and unsuccessful, and the physiologic changes during the SBT trial will be compared between the two groups, respectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06424314
Study type	Observational
Source	The First Affiliated Hospital of Guangzhou Medical University
Contact	Lili Guan, MD & PhD
Phone	020-81566675
Email	dr_nickguan@163.com
Status	Not yet recruiting
Phase
Start date	June 15, 2024
Completion date	December 1, 2025

View Details

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