The Effect of Doxapram Versus Theophylline on Diaphragmatic Function

Status Recruiting

Clinical Trial Summary

Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage.

Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.

Clinical Trial Description

This randomized comparative study will be conducted in the post-surgical cardio-thoracic intensive care unit in Beni -Suef University Hospital after approval of the department of anesthesiology, surgical ICU and pain management , and cardio thoracic department and the local ethics and research committee, and obtaining written informed consents from the patients to compare the effect of doxapram versus theophylline on diaphragmatic function using ultrasonography parameter: thickening fraction of the diaphragmatic muscle during respiration which defined as [(thickness at end-inspiration - thickness at end-expiration)/thickness at end-expiration] during spontaneous breathing trial as a primary outcome and its effect on weaning time and weaning success rate as secondary outcomes. ;

Study Design

Related Conditions & MeSH terms

Weaning Failure

Clinical Trial Details

NCT number	NCT03894189
Study type	Interventional
Source	Beni-Suef University
Contact	Samaa ak Rashwan, MD
Phone	020120159125
Email	samakassemrashwan@gmail.com
Status	Recruiting
Phase	N/A
Start date	May 2019
Completion date	December 2019

View Details

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