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Vision clinical trials

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NCT ID: NCT05533658 Completed - Cognitive Function Clinical Trials

The Effects of VisionPure™ on Indices of Vision Health and Cognitive Function

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

VisionPure™ is a softgel dietary supplement containing fish oil, lutein, zeaxanthin, and vitamin D. The intent of the VisionPure product is to assist in maintaining eye and cognitive health while helping to provide protection against blue throughout the day. In this pilot trial, approximately 16 participants will be recruited and randomly assigned to experimental and placebo conditions. Participants will consume 1 serving (2 softgels) per day of their respective study condition for 60 days. Prior to and following the 60 day supplementation period, participants will undergo a series of optometry and cognitive examinations to quantify eye health and cognitive function outcomes.

NCT ID: NCT05419713 Recruiting - Vision Clinical Trials

Intermediate Visual Space Perception

Start date: September 30, 2021
Phase: N/A
Study type: Interventional

The ability to judge the locations of various objects from oneself during self-motion in the intermediate distance range (~2-25m) is crucial for successful performance of activities of daily living, such as walking and driving. However, little is known about the mechanisms of visual space perception involved in judging distance, the focus of this project, in the planning and/or execution of self-motion in the natural 3D environment. The theoretical knowledge to be gained from this project will contribute to the scientific literature and provide insights into how eye and neurological defects could impair visual space perception, wayfinding, and mobility.

NCT ID: NCT04332783 Recruiting - Vision Clinical Trials

Isolating and Mitigating Sequentially Dependent Perceptual Errors in Clinical Visual Search

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

When looking at an x-ray, radiologists are typically asked to localize a tumor (if present), and to classify it, judging its size, class, position and so on. Importantly, during this task, radiologists examine on a daily basis hundreds and hundreds of x-rays, seeing several images one after the other. A main underlying assumption of this task is that radiologists' percepts and decisions on a current X-ray are completely independent of prior events. Recent results showed that this is not true: perception and decisions are strongly biased by past visual experience. Although serial dependencies were proposed to be a purposeful mechanism to achieve perceptual stability of otherwise noisy visual input, serial dependencies play a crucial and deleterious role in the everyday task performed by radiologists. For example, an x-ray containing a tumor can be classified as benign depending on the content of the previously seen x-ray. Given the importance and the impact of serial dependencies in clinical tasks, in this proposal, the investigators plan to (1) establish, (2) identify and (3) mitigate the conditions under which serial effects determine the participants' percepts and decisions in tumor search tasks. In Aim 1, the investigators will establish the presence of serial effects in four different clinically relevant domains: tumor detection, tumor classification, tumor position and recognition speed. In Aim 2, the investigators plan to identify the specific boundary conditions under which visual serial dependence impacts tumor search in radiology. In Aim 3, once the investigators fully understand these boundary conditions in Aim 2, they will propose a series of task and stimulus manipulations to control and mitigate the deleterious effects of visual serial dependence on tumor search. As a result of these manipulations, visual search performance should improve in measurable ways (detection, classification, position, speed). Aim 3 is particularly crucial because it will allow the investigators to propose new guidelines which will greatly improve tumor recognition in x-ray images, making this task even more effective and reliable. Taken together, the proposed studies in Aim 1, 2, and 3 will allow the investigators to establish, identify, and mitigate the deleterious effect of serial dependencies in radiological search tasks, which could have a significant impact on the health and well-being of patients everywhere.

NCT ID: NCT04065061 Completed - fMRI Clinical Trials

Erinacine A-enriched Hericium Erinaceus Mycelia for Improvement of Recognition, Vision, and Functional MRI Alterations

Start date: May 22, 2015
Phase: N/A
Study type: Interventional

This study was designed as randomized double blind placebo study to investigate the efficacy of Erinacine A-enriched Hericium erinaceus mycelia for improvement of recognition, vision, and functional MRI alterations.

NCT ID: NCT03884985 Recruiting - Vision Clinical Trials

Eye Movements, Visual Perception and Attention

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

During visual fixation, small eye movements of which we are usually not aware, prevent the maintenance of a steady direction of gaze. These eye movements are finely controlled and shift retinal projection of objects within the fovea, the region of the retina where visual acuity is highest. This program of research examines the link between these eye movements and attention, and tests the hypothesis that attention, similarly to eye movements, can be controlled at the foveal level. Psychophysical experiments with human subjects, using state-of-the-art techniques, high resolution eyetracking and retinal stabilization are conducted to address these questions. Gaze-contingent calibration procedures are employed to achieve high accuracy in gaze localization. A custom developed gaze-contingent display is used to shift in real-time visual stimuli on the monitor to compensate for the observer eye movements during fixation periods and to maintain stimuli at a desired location on the retina. Experiments involve visual discrimination/detection tasks with stimuli presented at selected eccentricities within the fovea. Participants' performance and reaction times are examined under different conditions, in which various types of attention are manipulated. In addition to advancing our basic understanding of visual perception, this research leads to a better understanding of attentional control at the foveal scale and of the contribution of microscopic eye movements to the acquisition and processing of visual details.

NCT ID: NCT02033200 Completed - Vision Clinical Trials

Safety Study Looking at the Effects of Stendra on Vision

Start date: January 2014
Phase: Phase 4
Study type: Interventional

The purpose of this study is to see if Stendra causes any changes in vision, eye pressure, pupil dilation, and color vision in healthy males.

NCT ID: NCT01138228 Completed - Vision Clinical Trials

Does the VTS1000 Infra Red Vein Imager Allow Better Identification of Veins Than Normal Eyesight?

VFvalidation
Start date: February 2010
Phase: N/A
Study type: Observational

VueTek has developed a head mounted device that will improve the viewing of superficial, subcutaneous vasculature, differentiating it with higher contrast from surrounding tissue. Video of the vasculature is displayed to the user in a portable headset. The headset and display combination facilitates both visualization in the display and an open field of view directly to the subject's anatomy and practitioner's surroundings. The goal is to provide a non-diagnostic, enhanced visual aide that is used alongside standard visual and tactile methodology. The primary and secondary objectives of this validation are as follows: 1. Primary Objective: To demonstrate that the VTS1000 affords visualization of superficial, subcutaneous vascular structures, when compared to the naked eye. 2. Secondary Objective: To demonstrate that the VTS1000 enhances visualization of superficial, subcutaneous vascular structures over the naked eye. Validation Ancillary Endpoints 1. To gather data to demonstrate that the VTS1000 is portable, affords conventional vascular access methods, and provides flexibility, fit and balance during use.

NCT ID: NCT01062672 Withdrawn - Stroke Clinical Trials

Functional Neuroimaging of Cortical Plasticity in the Human Visual System

Start date: January 2009
Phase:
Study type: Observational

The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

NCT ID: NCT01057966 Completed - Vision Clinical Trials

Bioavailability of Nutrients Contained in Softgel Capsules vs Tablets

Start date: February 2010
Phase: Phase 4
Study type: Interventional

This study is a comparison of the bioavailability of nutrients contained in softgel capsules vs tablets.

NCT ID: NCT00886249 Withdrawn - Cataract Clinical Trials

Depth of Focus Comparison Between Acrysof IQ and Acrysof Natural IOLs

Start date: March 2009
Phase:
Study type: Observational

The purpose of this study is to evaluate and compare the depth of focus and visual outcomes after implantation of the Acrysof IQ SN60WF aspheric intraocular lens (IOL) and the Acrysof Natural SN60AT spherical IOL.