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Viral Infection clinical trials

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NCT ID: NCT05897801 Completed - Clinical trials for Bacterial Infections

Distinguishing Bacterial and Viral Infections by MeMed BV® Test to Limit Gut Colonization by MDRO

CRONUS
Start date: May 29, 2023
Phase:
Study type: Observational

The fast increase of Multidrug-resistant microorganisms (MDRO) due to the high amount of antimicrobials being poorly used may be limited by better regulating antimicrobial usage globally. The goal of this observational study is the performance of the MeMed BV® test in the MeMed Key® device at the emergency department to a) support the differential diagnosis between bacterial and viral infections of the respiratory tract and b) provide evidence of how the use of this test may limit gut colonization by MDRO.

NCT ID: NCT05717283 Completed - Clinical trials for Microbial Colonization

Follow-up of the Nasal Microbiome and Viral Infections in Newborns Hospitalised in Neonatology.

NEOBIOME
Start date: December 20, 2022
Phase: N/A
Study type: Interventional

The goal of this interventional study is to learn about nasal microbiome and viral infections in newborns hospitalised in neonatology. The main questions it aims to answer are : - how often are newborns infected by viruses in neonatology ? - how does the microbiome develop during first weeks of life ? - how does microbiome and viruses interacts together ? - is there a link between viral infection, microbiome, and medical complications during hospitalisation in neonatology ? Participants will have a nasal swab taken each week during their hospitalisation in neonatology, and researchers will take medical data from the medical chart.

NCT ID: NCT05467007 Completed - Clinical trials for Acute Respiratory Infection

Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway

URGENT
Start date: April 4, 2022
Phase: N/A
Study type: Interventional

Rapid diagnosis and precise treatment have become possible with multiplex polymerase chain reaction (PCR) panels that can identify a variety of causative agents of acute respiratory illnesses such as bacterial and viral infections in one urgent care visit. While real-time PCR is currently used as a standard for diagnosing acute respiratory illnesses such as influenza due to its high sensitivity and specificity, it typically takes several hours for results which is unfavorable in the urgent care setting. Highly sensitive and rapid random-access PCR tests provide the sensitivity and specificity needed to both rapidly and accurately diagnose acute respiratory illnesses. Similar PCR panels have been used in previous research for the diagnosis of gastrointestinal illnesses in the emergency department and point-of-care testing for hospitalized adults presenting with acute respiratory illness. In this study, the investigators aim to determine if a rapid multiplex PCR test for urgent care patients with symptomatic upper respiratory infections can improve patient and provider-reported outcomes. This study utilizes the Biofire® FilmArray Panel (RP2.1-EZ) which in previous studies has been shown to be highly effective in diagnosing acute respiratory illnesses.

NCT ID: NCT05412173 Completed - COVID-19 Clinical Trials

Pharmacokinetics and Bioequivalence of Molnupiravir, 200 mg Capsules and Lagevrio, 200 mg Capsules in Healthy Volunteers

Start date: April 22, 2022
Phase: N/A
Study type: Interventional

The study aimed for: 1. Comparative evaluation of the safety of the drug Molnupiravir, capsules, 200 mg (JSC "Valenta Pharm", Russia), and Lagevrio, capsules, 200 mg (Merck Sharp & Dohme (UK) Limited, UK), based on the analysis of adverse events (AEs); 2. Comparative assessment of pharmacokinetic parameters and bioequivalence of the drug Molnupiravir, capsules, 200 mg (Valenta Pharm JSC, Russia), and Lagevrio, capsules, 200 mg (Merck Sharp & Dohme (UK) Limited, UK), in healthy volunteers in fasted conditions.

NCT ID: NCT05385445 Completed - Dementia Clinical Trials

Electronic Medical Records to Increase Adherence to the Choosing Wisely Recommendations

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

Audit and Feedback (A&F), a strategy aimed at promoting modified practice through performance feedback, is a method to change provider behaviour and reduce unnecessary medical services. This study aims to assess the use of A&F to change: 1. antibiotic prescribing for viral infections 2. antipsychotic prescribing to patients with dementia 3. routine measure of vitamin D in low risk adults 4. annual screening blood tests (without direct indication by the risk profile of the patient)

NCT ID: NCT05226949 Completed - Neonatal Sepsis Clinical Trials

Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus Infection

Start date: January 1, 2022
Phase:
Study type: Observational

This study seeks to identify and test host RNA expression profiles in context to protein biomarkers in dried blood spot samples as novel diagnostic markers of neonatal herpes simplex virus infection and to improve the understanding of the pathogenesis of the disease.

NCT ID: NCT05090475 Completed - Viral Infection Clinical Trials

Implementation of Academic Detailing Interventions on Prescribing of Antimicrobial Drugs in Primary Health Care

Start date: April 1, 2020
Phase: N/A
Study type: Interventional

World increase in mortality from consequences of antimicrobial resistance (AMR) represents a significant public health problem. Irrational prescribing of antimicrobial drugs (AMD) in general population is one of the main causes of development AMR. This is also contributed by fact that up to 90% of total antimicrobial consumption in Europe is related to the general population. Problem of AMR has been recognized by World Health Organization and Council of European Union, which support the establishment of the antimicrobial stewardship team (A-team). A-team provides co-ordinated interventions that promote rational use of AMD. To date, no study has been carried out in which A-team from hospital environment goes to primary health care for the purpose of rationalization prescribing of AMD by primary health care practitioners. Project for implementation of hospital A-team in primary health care in Koprivnica-KriĹževci County was initiated using academic detailing method aimed at rationalization of the consumption of AMD.

NCT ID: NCT04980534 Completed - Covid19 Clinical Trials

Evaluation of the Effectiveness of Therapy for Patients With Covid-19 Using Food Supplements Viusid + Asbrip

Start date: January 8, 2021
Phase: N/A
Study type: Interventional

This is a two-arm, randomized, open label, monocenter, controlled study to evaluate the safety and efficacy of Viusid plus Asbrip in patients with mild and moderate symptoms of respiratory illness caused by Coronavirus 2019 infection.

NCT ID: NCT04823026 Completed - Sepsis Clinical Trials

Host RNA Profiles to Detect Infections in Young Infants

CHILD_YIC
Start date: May 15, 2020
Phase:
Study type: Observational

This study seeks to identify and test host RNA expression profiles as markers for infections in young infants. Preliminary studies have shown high sensitivity and specificity for the discrimination of bacterial from non-bacterial infections in children, but the method has only been investigated in a limited number of young infants. The study aims to include 65 young infants with serious bacterial infections. The samples will be analysed by RNA sequencing. New diagnostic tools may help reduce unnecessary antibiotic treatment, antibiotic resistance, side-effects, hospitalisation and invasive procedures.

NCT ID: NCT04777747 Completed - Clinical trials for Bacterial Infections

The Role of Lactate in Viral and Bacterial Infection

Start date: January 1, 2021
Phase:
Study type: Observational

Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.