Pulmonary Hypertension Clinical Trial
Intraoperative myocardial and pulmonary protection is important for better outcome after
cardiac surgery. Ischemic preconditioning is one of organ protective strategies against
ischemia-reperfusion injury by applying brief ischemia to the target organ before a
subsequent critical ischemia, and its effect has been confirmed. However, its clinical
application is not easy because ischemic insult may aggravate the function of vulnerable
organ.
On the other hand, remote ischemic preconditioning (RIPC) is another protective approach by
applying ischemia to other less vulnerable organ such as skeletal muscle before critical
ischemia-reperfusion injury to heart. The effect of RIPC has been well demonstrated in
adults and children. However, Little is known about the effect of remote ischemic
precondition on the pediatric myocardium to ischemia and reperfusion injury. The effect of
RIPC on the children remains to be further evaluated because the degree of
ischemia-reperfusion injury is different according to age, cardiac pathology and cyanosis.
In addition, the previous report on children dealt with a diverse range of congenital heart
defects with a wide age range. The purpose of this study was to evaluate the effect of RIPC
on myocardial and pulmonary protection in infants with pulmonary hypertension who need
repair of simple ventricular septal defect.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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