Venous Thrombosis Clinical Trial
Official title:
Association of Thrombophilia and Inflammation With Post-Thrombotic Syndrome
Venous thrombosis is the development of a blood clot in a vein. Post-thrombotic syndrome (PTS) is a painful condition that can develop following a venous thrombosis in one of the deep veins of the leg. While PTS is mainly thought to occur because of damage to the vein, other factors may be responsible for the development of this condition. This study will analyze genetic and biologic samples from participants of a previous study to examine other possible causes of venous diseases and PTS.
The long-term effects of venous thrombosis, known collectively as PTS, include persistent
swelling, pain, cramps, and numbness in the leg. These symptoms result from impaired return
of blood through the veins of the lower leg to the heart. PTS is believed to occur as a
result of direct damage to the valves and walls of the vein. There may be specific factors
that make certain individuals more prone to PTS. Individuals who are obese, have a genetic
predisposition to blood clotting disorders, or have high levels of inflammation biomarkers
may have an increased risk of developing venous diseases. The purpose of this study is to
investigate the possible link between these factors and the occurrence of chronic venous
disease and PTS. The study's findings will be useful in developing new prevention and
treatment strategies.
This study will examine previously collected data from participants in the San Diego
Population Study, a study that gathered information on the prevalence of chronic venous
disease in a multi-ethnic group of individuals. There will be no study visits specifically
for this study. Researchers will examine stored genetic and biologic samples of 370 control
participants and 370 participants with chronic venous disease. Specifically, levels of
inflammation biomarkers, levels of obesity-related biomarkers, and genetic predispositions
for blood clotting disorders will be studied.
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Observational Model: Cohort, Time Perspective: Retrospective
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