Obstructive Sleep Apnea Clinical Trial
Official title:
Use of CPAP to Reduce Arterial Stiffness in Moderate to Severe Obstructive Sleep Apnea, Without Excessive Daytime Sleepiness (STIFFSLEEP)
This study intends to determine whether continuous positive airway pressure (CPAP) can reduce arterial stiffness (measured by pulse wave velocity) in nonsleepy as well as in sleepy patients with obstructive sleep apnea .
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and
mortality. Arterial stiffness, evaluated by pulse wave velocity, is related to
atherosclerosis and cardiovascular risk. It has been reported that arterial stiffness is
higher in patients with OSA than in healthy control groups, and it is assumed that it
decreases after treatment with CPAP.
In patients with OSA without daytime hypersomnolence it is not clear if CPAP has some
benefits on cardiovascular events and hypertension.
This study aims to evaluate the effect of CPAP therapy in an interventional cohort of
patients with moderate to severe OSA, in which each patient will be is own control, for
ethical reasons; the effect of CPAP therapy on the subcohorts of sleepy and of nonsleepy
patients will be compared. The effect of a three months trial of CPAP will be assessed.
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