Vascular Inflammation Clinical Trial
Official title:
Linagliptin as a Modulator of Vascular Inflammation in Patients With Type 2 Diabetes Mellitus
Examination of the effect of Linagliptin versus placebo for 6 months on vascular
inflammation of the carotic artery and on abdominal adipose tissue inflammation in patients
with diabetes mellitus type 2. The effect will be assessed by FDG-PET scan.
Furthermore the effect of Linagliptin on the vessel wall volume of the carotid artery will
be assessed by MRI scan and biomarkers of vascular inflammation will be analyzed in blood
samples.
As part of the screening a PET-CT scan is executed to examine baseline vascular inflammation
of the carotid artery and to evaluate abdominal adipose tissues inflammation.
Patients who are eligible to participate in the study according to the in- and exclusion
criteria will be randomised in one of the two study arms.
According to the randomisation the patients will receive 5 mg Linagliptin or placebo per day
for a period of 6 months.
To evaluate the effect of Linagliptin versus placebo the vessel wall volume of the artery
will be assessed by MRI scan and the vascular inflammation of the carotid artery by FDG-PET,
furthermore the vascular inflammation will be analyzed by biomarkers in blood samples and
the abdominal adipose tissue inflammation will investigated by subcutaneous adipose tissue
biopsies.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02305953 -
Cytokines and Vascular Inflammation in Psoriasis
|
N/A | |
| Recruiting |
NCT04620876 -
Bimodal and Coaxial High Resolution Ophtalmic Imaging
|
N/A | |
| Completed |
NCT01722214 -
Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis
|
Phase 4 | |
| Active, not recruiting |
NCT04444128 -
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
|
||
| Recruiting |
NCT05812755 -
SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
|
Phase 4 | |
| Recruiting |
NCT05195164 -
The Effects of Orchiectomy and Age on Vascular and Metabolic Health in Older Versus Younger Transgender Women
|
||
| Completed |
NCT05730634 -
The Effect of Statin Treatment on Arterial Wall Inflammation as Assessed With 68Ga-DOTATATE PET-CT
|
N/A | |
| Completed |
NCT00940862 -
Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis
|
Phase 4 | |
| Recruiting |
NCT04129021 -
Multimodal Ophthalmic Imaging
|
N/A | |
| Recruiting |
NCT04237467 -
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
|
||
| Recruiting |
NCT06083337 -
Vascular Inflammation ReDuction and Perivascular Fat Imaging by Computed Tomography
|
N/A | |
| Completed |
NCT02926807 -
Trial on Vascular Inflammation in Atopic Dermatitis
|
||
| Recruiting |
NCT02379676 -
Effect of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation
|
Phase 4 | |
| Completed |
NCT02576067 -
Cardiovascular Inflammation Reduction Trial - Inflammation Imaging Study
|
Phase 3 | |
| Recruiting |
NCT05619653 -
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19
|
Phase 3 | |
| Terminated |
NCT02109289 -
Etanercept in Rheumatoid Arthritis and Vascular Inflammation
|
Phase 4 | |
| Recruiting |
NCT04066283 -
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
|