Vascular Function Clinical Trial
— UMMC_PilotOfficial title:
Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1
Verified date | October 2023 |
Source | University of Mississippi Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The research aims of this proposal are: - Specific Aim 1: To test whether an increase in nitric oxide signaling can increase vasodilator responses in young Black individuals. - Specific Aim 2: To test whether a decrease in endothelin-1 signaling can increase vasodilator responses in young Black individuals.
Status | Terminated |
Enrollment | 8 |
Est. completion date | September 20, 2021 |
Est. primary completion date | September 20, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Self-identification of their race and the race of their biological parents as being only Black (i.e., African American) or only White (i.e., Caucasian American) - Born and raised in the United States Exclusion Criteria: - Mixed races - Any chronic or ongoing disease - Prescribed pharmacological treatment - Smoking or tobacco use - Obesity (body mass index > 30 kg / m2) |
Country | Name | City | State |
---|---|---|---|
United States | University of Mississippi Medical Center | Jackson | Mississippi |
Lead Sponsor | Collaborator |
---|---|
University of Mississippi Medical Center |
United States,
Barbosa TC, Kaur J, Stephens BY, Akins JD, Keller DM, Brothers RM, Fadel PJ. Attenuated forearm vascular conductance responses to rhythmic handgrip in young African-American compared with Caucasian-American men. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1316-H1321. doi: 10.1152/ajpheart.00387.2018. Epub 2018 Aug 17. — View Citation
Barbosa TC, Young BE, Stephens BY, Nandadeva D, Kaur J, Keller DM, Fadel PJ. Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise. Am J Physiol Regul Integr Comp Physiol. 2020 Sep 1;319(3):R323-R328. doi: 10.1152/ajpregu.00105.2020. Epub 2020 Aug 12. — View Citation
Kaur J, Barbosa TC, Nandadeva D, Young BE, Stephens BY, Brothers RM, Fadel PJ. Attenuated Rapid-Onset Vasodilation to Forearm Muscle Contraction in Black Men. Med Sci Sports Exerc. 2021 Mar 1;53(3):590-596. doi: 10.1249/MSS.0000000000002511. — View Citation
Vranish JR, Holwerda SW, Young BE, Credeur DP, Patik JC, Barbosa TC, Keller DM, Fadel PJ. Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men. Hypertension. 2018 Jan;71(1):192-198. doi: 10.1161/HYPERTENSIONAHA.117.10229. Epub 2017 Dec 4. — View Citation
Young BE, Kaur J, Vranish JR, Stephens BY, Barbosa TC, Cloud JN, Wang J, Keller DM, Fadel PJ. Augmented resting beat-to-beat blood pressure variability in young, healthy, non-Hispanic black men. Exp Physiol. 2020 Jul;105(7):1102-1110. doi: 10.1113/EP088535. Epub 2020 May 27. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Flow-mediated Dilation | The percent change in arterial diameter normalized to arterial shear rate during reperfusion after 5 minutes of circulatory occlusion. | Within 4 hours of drug/supplement administration. | |
Primary | Reactive Hyperemia (Cuff Release) | Blood velocity area-under-the-curve from the beginning of reperfusion to return to resting values. | Within 4 hours of drug/supplement administration. | |
Primary | Muscle Hyperemia (Passive Leg Movement) | Peak and the area-under-the-curve of the change in femoral artery blood flow during 1 minute of passive leg movement. | Within 4 hours of drug/supplement administration. | |
Primary | Muscle Hyperemia (Rhythmic Handgrip Exercise) | Changes in brachial artery blood flow and conductance during single handgrip contractions at 3 intensities. | Baseline measurements with no drug/supplement administration before or after. | |
Primary | Muscle Hyperemia (Rhythmic Knee Extension Exercise) | Changes in femoral artery blood flow and conductance during 3 minutes of rhythmic knee extension exercise. | Within 4 hours of drug/supplement administration. |
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