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Nitrate and Brain Insulin-Sensitivity — NO-BRAINS  

Vascular Function Clinical Trial

Official title:
Acute Effects of Inorganic Nitrate on Brain Insulin-sensitivity in Abdominally Obese Men

Clinical Trial Summary

Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia. Inorganic nitrate may improve brain insulin-sensitivity, which can be quantified by measuring the gray-matter cerebral blood flow (CBF) response to intranasally administered insulin, through beneficial effects on brain vascular function. Therefore, we now hypothesize that inorganic nitrate, which can be found in several vegetables such as beetroot, improves brain insulin-sensitivity, as assessed by the gray-matter CBF response to intranasally administered insulin, in abdominally obese men.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04700241
Study type Interventional
Source Maastricht University Medical Center
Contact
Status Completed
Phase N/A
Start date January 21, 2021
Completion date May 5, 2021
View Details
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