Vascular Function Clinical Trial
Official title:
Comparison of Vascular Function in Emergency Service Professionals
Emergency Service Professionals have an increased risk of death from heart attacks when
compared to the general public. All the emergency professions share similar responsibilities
such as emergency call-outs and shift work. Heart disease is the commonest cause of on-duty
death amongst fire-fighters accounting for 45% and compared with 22% in police officers and
15% in the general population. The unique risk to fire-fighters is likely to reflect a
combination of factors including extreme physical exertion, mental stress, heat and
pollutant exposure.
In this study the investigators will assess healthy career fire-fighters and age-matched
healthy police officer control subjects following a sedentary period. The investigators will
take blood samples to measure platelet activity (platelets are the particles in blood that
help blood clot) and will examine how blood clots outside of the body. The investigators
will then perform studies placing small needles in the arm to assess how the blood vessels
respond following these duties. The investigators hypothesise that fire-fighters do not have
pre-existing impairment of heart, blood or blood vessel function as a cumulative effect of
their occupation, but rather these are acute and transitory effects following distinct
fire-fighter duties. We therefore expect similar results in both occupational groups.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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