Clinical Trials Logo
  1. Home
  2. Vascular Function
  3. NCT01812317

Effect of Real-fire Training on Vascular Function — FIREPROOF  

Vascular Function Clinical Trial

Official title:
Effect of Real-fire Training on Vascular Function

Clinical Trial Summary

Fire-fighters are at increased risk of death from heart attacks when compared to other emergency service professionals whose jobs involve similar components such as emergency call-outs and shift work. The unique risk to fire-fighters is likely to reflect a combination of factors including extreme physical exertion, mental stress, heat and pollutant exposure. In the largest analysis of cause of death amongst on-duty fire-fighters, fire-fighter deaths were classified according to the duty performed during the onset of symptoms or immediately prior to any sudden death. The majority of deaths due to a cardiovascular cause (i.e. heart attack) occurred during fire-suppression whilst this activity represented a relatively small amount of a fire-fighters professional time. Fire simulation training centers offer a unique opportunity to assess the heart, blood and blood vessel response to fire suppression in a controlled environment. In this study the investigators will assess healthy career fire-fighters on two occasions: following a fire-suppression training exercise in a purpose built real-fire training center, and following a sedentary period as a control. The investigators will take blood samples to measure platelet activity (platelets are the particles in blood that help blood clot) and will examine how blood clots outside of the body. The investigators will then perform studies placing small needles in the arm to assess blood vessel function following fire suppression. By undertaking this comprehensive assessment of blood, blood vessel and heart function we hope to understand the mechanisms whereby the risk of a heart attack is influenced by fire suppression. The investigators hypothesize that following the fire-suppression exercise firefighters blood will clot more readily and their blood vessels will not relax properly which are two of the main processes in the development of a heart attack.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01812317
Study type Interventional
Source University of Edinburgh
Contact
Status Completed
Phase N/A
Start date April 2012
Completion date September 2016
View Details
See also
  Status Clinical Trial Phase
Completed NCT03866343 - Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals N/A
Completed NCT02065271 - Herbal Preparation and Glucose Homeostasis N/A
Completed NCT01945970 - Effect of Black Tea on Vascular Function N/A
Completed NCT01495325 - Effect of Woodsmoke on Vascular Function N/A
Terminated NCT04239482 - Nutritional Supplementation and Insulin Sensitivity N/A
Completed NCT02273323 - Flow Mediated Dilation in Response to Black Tea N/A
Completed NCT04550026 - Cardiovascular Effects of Heated Tobacco Products (HTP) N/A
Completed NCT03849300 - Impacts of Aquatic vs Land Walking on Vascular Health and Exercise Tolerance in Patients With Peripheral Artery Disease N/A
Terminated NCT04770155 - Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1 Early Phase 1
Active, not recruiting NCT01312168 - Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment N/A
Recruiting NCT05468255 - The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults N/A
Completed NCT04700241 - Nitrate and Brain Insulin-Sensitivity N/A
Completed NCT02328339 - Tea and Forearm Blood Flow N/A
Completed NCT01575041 - The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function N/A
Completed NCT03324256 - Energy Drinks and Vascular Function N/A
Recruiting NCT01805063 - Effect of Fire Suppression and Emergency Duties on Vascular Function N/A
Not yet recruiting NCT06229873 - Smartphone App-guided Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure N/A
Completed NCT04175457 - The Acute Effects of E-cigarette Inhalation on Vascular Function, Microcirculation and Thrombosis N/A
Completed NCT01053026 - Evaluation of Effects of Exercise Training and ARB in DM Patients N/A
Completed NCT03625596 - Nutritional Supplements and Nitric Oxide Bioactivity N/A