Clinical Trials Logo

Clinical Trial Summary

Firefighters are at increased risk of death from heart attacks when compared to other emergencyy service professionals whose jobs involve similar components such as emergency call-outs and shift work. In the largest analysis of cause of death amongst on-duty firefighters, firefighter deaths were classified according to the duty performed during the onset of symptoms or immediately prior to any sudden death. The majority of deaths due to a cardiovascular cause (i.e. heart attack) occurred during fire suppression whilst this activity represented a relatively small amount of a firefighters professional time. There was also a risk of death associated with other duties such as emergency non-fire response and physical exertion. The investigators hypothesize that participation in active fire-fighting duties impairs blood vessel function and increases blood clot formation when compared with non-fire-fighting activities. In this study, healthy career firefighters will be assessed after three periods of duty: fire-suppression, emergency response without fire suppression and following a sedentary shift. The investigators will take blood samples to measure platelet activity (platelets are the particles in blood that help blood clot) and will examine how blood clots outside of the body. The investigators will then perform studies placing small needles in the arm to assess blood vessel function following these duties. By undertaking this comprehensive assessment of blood, blood vessel and heart function the investigators hope to understand the mechanisms whereby the risk of a heart attack, fatal or otherwise, is posed throughout these distinct duties that firefighters undertake on a daily basis.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01805063
Study type Observational
Source University of Edinburgh
Contact
Status Completed
Phase
Start date January 9, 2012
Completion date December 31, 2016

See also
  Status Clinical Trial Phase
Completed NCT03866343 - Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals N/A
Completed NCT02065271 - Herbal Preparation and Glucose Homeostasis N/A
Completed NCT01945970 - Effect of Black Tea on Vascular Function N/A
Completed NCT01495325 - Effect of Woodsmoke on Vascular Function N/A
Terminated NCT04239482 - Nutritional Supplementation and Insulin Sensitivity N/A
Completed NCT02273323 - Flow Mediated Dilation in Response to Black Tea N/A
Completed NCT04550026 - Cardiovascular Effects of Heated Tobacco Products (HTP) N/A
Completed NCT03849300 - Impacts of Aquatic vs Land Walking on Vascular Health and Exercise Tolerance in Patients With Peripheral Artery Disease N/A
Terminated NCT04770155 - Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1 Early Phase 1
Active, not recruiting NCT01312168 - Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment N/A
Not yet recruiting NCT06440512 - The Effect of Chocolate on Vascular Function of Endurance Runners N/A
Not yet recruiting NCT06229873 - Smartphone App-guided Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure N/A
Recruiting NCT05468255 - The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults N/A
Completed NCT04700241 - Nitrate and Brain Insulin-Sensitivity N/A
Completed NCT02328339 - Tea and Forearm Blood Flow N/A
Completed NCT01575041 - The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function N/A
Completed NCT03324256 - Energy Drinks and Vascular Function N/A
Completed NCT04175457 - The Acute Effects of E-cigarette Inhalation on Vascular Function, Microcirculation and Thrombosis N/A
Completed NCT01053026 - Evaluation of Effects of Exercise Training and ARB in DM Patients N/A
Completed NCT03625596 - Nutritional Supplements and Nitric Oxide Bioactivity N/A