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Varicose Veins clinical trials

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NCT ID: NCT02441881 Completed - Varicose Veins Clinical Trials

Trial of Radiofrequency Thermo-ablation Treatments of Great Saphenous Varicose Veins (3-RF Study)

Start date: September 5, 2014
Phase: N/A
Study type: Interventional

A double blind randomised controlled trial of radiofrequency thermal ablation treatments of great saphenous varicose veins: Venefit (Closurefast), vs. Radiofrequency induced Thermal Therapy vs. Endovenous Radiofrequency. Assessments by visual pain scores, duplex ablation and quality of life questionaires

NCT ID: NCT02397226 Active, not recruiting - Varicose Veins Clinical Trials

Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery

Start date: September 1, 2014
Phase: N/A
Study type: Interventional

200 patients with insufficient great saphenous veins will be randomized to either radiofrequency ablation or high ligation/stripping (open surgery). They will be examined according to standardized examination protocol Venous Clinical Severity Score (VCSS), with duplex ultrasound and plethysmography pre- and postoperatively (1-month, 1-, 3 and 5 years). They are to fill questionnaires EuroQol 5 Dimensions (EQ-5D) and disease specific Aberdeen Varicose Vein Questionnaire (AVVQ).

NCT ID: NCT02346058 Completed - Clinical trials for Chronic Venous Insufficiency

Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins

Start date: October 2013
Phase: Phase 4
Study type: Interventional

Evaluation efficacy and safety of Esarin Gel in subjects with chronic venous insufficiency or varicose veins combine superficial vein thrombophlebitis.

NCT ID: NCT02345018 Completed - Varicose Veins Clinical Trials

Primary Insufficiency of the GSV With a Diameter >/= 12 mm, Antero-lateral Branches, or Below the Knee

MOCA-XL
Start date: June 2016
Phase:
Study type: Observational [Patient Registry]

The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches and insufficiency of the GSV below the knee.

NCT ID: NCT02335580 Completed - Liver Cirrhosis Clinical Trials

Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis

Start date: December 2014
Phase:
Study type: Observational

The prevalence of portal vein thrombosis (PVT) in patients with liver cirrhosis is 5-20%. Current evidence regarding the effect of portal vein thrombosis on the prognosis of cirrhotic patients remains under debate. Considering that PVT potentially elevates the portal pressure and thereby increase the risk of variceal bleeding, we focus on the patients with high-risk varices and variceal bleeding as the study population. Thus, the main goals are to analyze the effect of PVT on the incidence of first variceal bleeding in patients without any prior bleeding history but with high-risk varices, the incidence of recurrent variceal bleeding in patients with a history of variceal bleeding, and the treatment failure rate of variceal bleeding in patients with acute variceal bleeding. Certainly, the survival is also observed in all patients.

NCT ID: NCT02304146 Recruiting - Varicose Veins Clinical Trials

Long-term Ultrasound Guided Foam Sclerotherapy Versus Classical Surgical Stripping Study

Start date: November 2014
Phase: N/A
Study type: Observational [Patient Registry]

The aim of this study is to investigate the long-term follow-up of the previously conducted FOAM study.

NCT ID: NCT02241707 Withdrawn - Clinical trials for Venous Insufficiency

Does Minimal Post-operative Compression Affect the Outcome for Endovenous Ablation in Treating Varicose Vein Patients?

Start date: August 2014
Phase: N/A
Study type: Observational [Patient Registry]

In this proposal, the investigators seek to determine whether a reduced compression after endovenous ablation procedure in treating superficial venous insufficiency affects the outcomes. This study involves only the use of the compression stocking post endovenous ablation procedure and everything else is standard according to current guidelines. The investigators general strategy will be to determine the role of a minimal post-operative compression and the status of patient satisfaction including (1) Success closure rate of the treated vein. (2) Less pain; (3) Easier accepted by the patients.

NCT ID: NCT02139085 Recruiting - Varicose Veins Clinical Trials

Great Saphenous Vein Electrocoagulation

Start date: August 2014
Phase: Phase 2
Study type: Interventional

Introduction: Lower extremity Chronic Venous Insufficiency is a prevalent disease that adversely affects an individual's Quality of Life. Varicose vein endovenous radiofrequency treatment have a lower risk of iatrogenic injuries and offer faster return to work activities, when compared with open surgical techniques. Endovenous electrocoagulation can selectively and safely cause Great Saphenous Vein (GSV) wall necrosis but its clinical results has never been studied before. Objective: The objective of this study is to compare Great Saphenous Vein electrocoagulation and radio frequency (RF) endovascular varicose vein treatment clinical results and quality of life improvement in a prospective double blind randomized controlled clinical trial. Methods: Consecutive patients with varicose veins and primary GSV reflux will be randomized to Electrocoagulation or Radiofrequency endovenous treatment. The primary outcome measure will be GSV occlusion rate at 3 and 6 months after treatment verified by Duplex Scanning (DS). Secondary outcome measures will be pain visual analogue scale (VAS), bruising, neuropathy and vein thrombosis frequency in the immediate postoperative period (1 week); and Clinical Etiology Anatomy and Pathophysiology (CEAP) classification ,Venous Clinical Severity Scale (VCSS), and Aberdeen Varicose Vein Questionnaire (AVVQ), obtained preoperatively, at 3 and 6 months postoperatively. For statistical analysis, we will use the Student's t test, the Mann-Whitney test and Pearson's correlation, considering positive statistical significance when level of p <0.05.

NCT ID: NCT02115061 Recruiting - Gastric Varices Clinical Trials

Gastric Varices Treatment: Coil + Cyanoacrylate Versus Cyanoacrylate

Start date: August 2013
Phase: Phase 1
Study type: Interventional

The purpose of the spring is to maintain the cyanoacrylate polymer of the gastric varix, forming a conglomerate spring-cyanoacrylate, and thus preventing their migration to the adhesive embolism. The introduction of the spring is held by a echo-guided puncture. The window can be puncture through the distal esophagus or directly in the gastric varix via retroflexion to the fundus. Another advantage of this technique is its use in the presence of bleeding, when large amounts of blood in the stomach hinders the injection of the cyanoacrylate, by pricking the distal esophagus that difficulty decreases. The first study of this technique was performed by Binmoeller et al (21) and had good results with 100% hemostasis and low rebleeding rate (16%), but more studies are needed to prove the safety and efficacy of this technique.

NCT ID: NCT02114307 Completed - Varicose Veins Clinical Trials

REVITIVE for the Treatment of Patients With Venous Insufficiency

RVI
Start date: March 1, 2014
Phase: N/A
Study type: Interventional

To investigate the efficacy of an electrical stimulation (using the REVITIVE IX device) in treating patients with venous insufficiency.