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Vaccination Efficacy With Metformin in Older Adults — VEME  

Aging Clinical Trial

Official title:
Vaccination Efficacy With Metformin in Older Adults: A Pilot Study

Clinical Trial Summary

With aging the immune system gets weaker. This makes older adults more susceptible to influenza (flu). Vaccinations help to prevent infection from the flu virus, however the immune system of older adults do not respond as well to vaccines compared to young adults and thus, aren't as well protected from the complications from the flu. This research is being done to determine if Metformin, an FDA-approved diabetes medication, is effective at enhancing immune responses to flu vaccine in older men and women. Participants will be randomly assigned to either metformin or placebo treatment for a total of 22 weeks. Participants will be vaccinated with high-dose flu vaccine after 12 weeks of treatment. Immune responses will be evaluated throughout the study at 6 time points.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03996538
Study type Interventional
Source UConn Health
Contact
Status Completed
Phase Phase 1
Start date June 5, 2019
Completion date February 4, 2020
View Details
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