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Clinical Trial Summary

This research study is being done to investigate how Azenosertib affects tumor cells of persistent or recurrent uterine serous carcinoma. The name of the study drug involved in this study is: -Azenosertib (a type of Wee1 inhibitor)


Clinical Trial Description

This research study is being done to investigate how Azenosertib affects tumor cells of persistent or recurrent uterine serous carcinoma. Azenosertib has been tested as a treatment for other diseases and has shown to stop cancer cell growth. The U.S. Food and Drug Administration (FDA) has not approved Azenosertib as a treatment for recurrent uterine serous carcinoma. This research study involves screening for eligibility, study treatment visits, X-rays, Computerized Tomography (CT) scans, Magnetic Resonance Imaging (MRI) scans, Positron Emission Tomography CT (PET-CT) scans, Meta-iodobenzylguanidine (MIBG) scans, Fluorodeoxyglucose Positron Emission Tomography), (FDG-PET) scans, Electrocardiograms (EKGs), tumor biopsies, and blood tests. It is expected that about 25 people will take part in this research study. Zentalis Pharmaceuticals is supporting this research study by providing the study drug Azenosertib. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06369155
Study type Interventional
Source Dana-Farber Cancer Institute
Contact Joyce Liu, MD, MPH
Phone 617-632-5269
Email Joyce_Liu@DFCI.HARVARD.EDU
Status Not yet recruiting
Phase Phase 2
Start date September 2024
Completion date January 31, 2027

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