Azenosertib in Uterine Serous Carcinoma: Biomarker Study

Status Not yet recruiting

Clinical Trial Summary

This research study is being done to investigate how Azenosertib affects tumor cells of persistent or recurrent uterine serous carcinoma. The name of the study drug involved in this study is: -Azenosertib (a type of Wee1 inhibitor)

Clinical Trial Description

This research study is being done to investigate how Azenosertib affects tumor cells of persistent or recurrent uterine serous carcinoma. Azenosertib has been tested as a treatment for other diseases and has shown to stop cancer cell growth. The U.S. Food and Drug Administration (FDA) has not approved Azenosertib as a treatment for recurrent uterine serous carcinoma. This research study involves screening for eligibility, study treatment visits, X-rays, Computerized Tomography (CT) scans, Magnetic Resonance Imaging (MRI) scans, Positron Emission Tomography CT (PET-CT) scans, Meta-iodobenzylguanidine (MIBG) scans, Fluorodeoxyglucose Positron Emission Tomography), (FDG-PET) scans, Electrocardiograms (EKGs), tumor biopsies, and blood tests. It is expected that about 25 people will take part in this research study. Zentalis Pharmaceuticals is supporting this research study by providing the study drug Azenosertib. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06369155
Study type	Interventional
Source	Dana-Farber Cancer Institute
Contact	Joyce Liu, MD, MPH
Phone	617-632-5269
Email	Joyce_Liu@DFCI.HARVARD.EDU
Status	Not yet recruiting
Phase	Phase 2
Start date	September 2024
Completion date	January 31, 2027

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