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Urolithiasis clinical trials

View clinical trials related to Urolithiasis.

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NCT ID: NCT01295879 Completed - Clinical trials for Vitamin D Deficiency

Vitamin D Repletion in Stone Formers With Hypercalciuria

Start date: September 2010
Phase: Phase 4
Study type: Interventional

Vitamin D plays a critical role in maintaining bone health, as well as preventing cardiovascular disease, cancer, and various autoimmune diseases, such as diabetes. Vitamin D deficiency is very common in the United States and worldwide, and is now being increasingly recognized and treated. One group in which vitamin D deficiency may be particularly important is patients who have had kidney stones. These patients frequently have elevated levels of calcium in their urine, which is a common and important risk factor for calcium containing kidney stones. Because vitamin D increases absorption of calcium into the blood by the intestines, physicians may be reluctant to prescribe vitamin D therapy to patients with vitamin D deficiency if they also have kidney stones and high amounts of calcium in the urine. They are concerned about the possible risk of increasing the amount of calcium in the urine (and thereby increasing the risk of calcium stones occurring again). However, studies in patients without kidney stones, as well as studies in patients with high calcium levels in the urine, have demonstrated that giving vitamin D is effective and safe and does not increase calcium in the urine. Therefore, the investigators will study the effects of giving vitamin D on the amount of calcium in the urine in patients with a history of kidney stones and elevated calcium in the urine. The investigators will evaluate the safety of giving vitamin D to this particular group of patients.

NCT ID: NCT01246531 Completed - Clinical trials for Urolithiasis and Aging

Metabolic Assessment of Aging Men With Urinary Lithiasis

Start date: January 2008
Phase: N/A
Study type: Observational

Urinary lithiasis is a common disease on young adults, but not so far on aging people. Nowadays, the investigators are seeing a gradative growth on men above sixty years old, mainly in industrialized countries. The purpose of this study is to investigate metabolic aspects of aging men with renal stones, towards blood tests, 24 hour-urinary samples, imagenological exams and bone densitometry. The investigators have made a case-control model.

NCT ID: NCT01235104 Active, not recruiting - Urolithiasis Clinical Trials

Impact of Total Nephrectomy on Patients With Kidney Stone

Start date: January 2001
Phase: N/A
Study type: Observational

The aim of this study is to investigate the outcomes of total nephrectomy on patients with kidney stone disease.

NCT ID: NCT01144949 Completed - Urolithiasis Clinical Trials

Study of Silodosin to Facilitate Passage of Urinary Stones

Start date: June 2010
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess if patients treated with silodosin will have a higher spontaneous passage rate of their ureteral stone than those treated with placebo.

NCT ID: NCT01127854 Enrolling by invitation - Urolithiasis Clinical Trials

Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis

Start date: December 2009
Phase:
Study type: Observational

Recent investigations from this group have identified that genetic variants of genes associated with monogenic forms of nephrolithiasis are expressed in idiopathic calcium oxalate kidney stone patients and could influence stone forming risk. Utilizing patient samples from the Mayo Clinic Florida Kidney Stone Registry, we will demonstrate that expression of these heterozygous mutations in idiopathic nephrolithiasis act as genetic modifiers of disease presentation increasing risk of kidney stone formation. Complimented by the analysis of environmental and lifestyle risk factors, these studies will define environmental and genetic susceptibility factors involved in kidney stone formation and reoccurrence.

NCT ID: NCT01117688 Withdrawn - Urolithiasis Clinical Trials

Ureteroscopy With and Without Safety Guidewire

Start date: May 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the impact of a safety guidewire (SGW) on the results of ureteroscopy for urolithiasis. Study hypothesis: Routine use of SGW has no impact on the results of ureteroscopic treatment of urolithiasis.

NCT ID: NCT01022060 Completed - Clinical trials for Recurrent Calcic Urolithiasis

Renalof in the Dissolution of Renal Calculi in Patients With Recurrent Calcic Lithiasis

Start date: November 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether Renalof administration promotes partial or total dissolution of urinary calculi and improves physicochemical parameters and metabolic activity in patients with recurrent calcic urolithiasis. The duration of this double-blind placebo controlled phase 3 clinical trial will be 12 weeks. The estimated number of patients to be recruited and randomized for the study is 110. Ultrasonographic and humoral parameters will be assessed every 4 weeks.

NCT ID: NCT00913159 Terminated - Urolithiasis Clinical Trials

A Trial Comparing Efficacy of HM3 Versus F2 Lithotripters for Stone Fragmentation

Start date: November 2009
Phase: N/A
Study type: Interventional

The older lithotripter, HM3, has over 90% stone-free rate in most studies. However, it's less transportable than the new model, F2. There are no prospective trials performed to make a valid comparison between these 2 lithotripters in terms of efficacy of stone fragmentation and clinical outcomes.

NCT ID: NCT00907946 Terminated - Urolithiasis Clinical Trials

Comparing Previously Placed Nephrostomy Tract (NT) Versus Single Stage Percutaneous Nephrolithotomy (PCNL)

Start date: December 2009
Phase: N/A
Study type: Interventional

The investigators are trying to determine whether placement of a nephrostomy tube prior to definitive stone surgery and under ultrasonic or fluoroscopic guidance will reduce complications related to bleeding and infection compare to obtaining renal access at the time of surgery.

NCT ID: NCT00765531 Completed - Urolithiasis Clinical Trials

Stone Disease in Children and Their Families

Start date: n/a
Phase:
Study type: Observational

The hypothesis of this study proposal is that pediatric urinary stone formers have genetic risk factors which predispose their urinary stone production. 50-60% of pediatric stone patients have a positive family history of urinary stone disease. Several genetic mutations have been identified which predispose patients to various types of urinary stones. These genetic mutations can also lead to other significant sequela besides stones, including osteopenia/osteoporosis (bone loss). Furthermore, metabolic abnormalities can be identified in more than 50% of pediatric stone formers, some of which can be improved and/or alleviated with medical intervention to help decrease rate of stone formation and the need for hospitalization and surgical intervention.