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Ureteral Obstruction clinical trials

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NCT ID: NCT06412900 Not yet recruiting - Urolithiasis Clinical Trials

Radiomics and Image Segmentation of Urinary Stones by Artificial Intelligence

RISUS_AI
Start date: May 15, 2024
Phase:
Study type: Observational [Patient Registry]

Kidney stone disease causes significant morbidity, and stones obstructing the ureter can have serious consequences. Imaging diagnostics with computed tomography (CT) are crucial for diagnosis, treatment selection, and follow-up. Segmentation of CT images can provide objective data on stone burden and signs of obstruction. Artificial intelligence (AI) can automate such segmentation but can also be used for the diagnosis of stone disease and obstruction. In this project, the aim is to investigate if: Manual segmentation of CT scans can provide more accurate information about kidney stone disease compared to conventional interpretation. AI segmentation yields valid results compared to manual segmentation. AI can detect ureteral stones and obstruction or predict spontaneous passage.

NCT ID: NCT06382233 Recruiting - Clinical trials for Chronic Kidney Diseases

The PRO-FUTURE Project

PRO-FUTURE
Start date: January 30, 2024
Phase:
Study type: Observational

The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are: - Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? - Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?

NCT ID: NCT06349161 Completed - Clinical trials for Ureteropelvic Junction Obstruction

Long-term Outcome of Retroperitoneoscopic One-trocar-assisted Pyeloplasty: A Single-center and Single-surgeon Experience

Start date: May 2011
Phase:
Study type: Observational

Open surgical dismembered pyeloplasty has traditionally been the preferred method for treating ureteropelvic junction obstruction (UPJO), with a success rate exceeding 94%. However, it is associated with drawbacks such as increased postoperative pain, extended hospital stays, and visible scarring. Minimally invasive alternatives, including laparoscopic pyeloplasty (LP) and robot-assisted laparoscopic pyeloplasty (RALP), have gained popularity since their introduction in 1993, offering comparable success rates to open surgery while providing cosmetic benefits and shorter hospital stays. Nevertheless, these techniques present challenges in pediatric patients, including limited working space, technical complexities, and prolonged operative times. The retroperitoneoscopic one-trocar-assisted pyeloplasty (OTAP) method, introduced in 2007, combines the advantages of minimally invasive surgery with the success rates of standard dismembered pyeloplasty. Despite favorable outcomes reported by several researchers, comprehensive studies regarding long-term follow-up and clinical outcomes are lacking. This study aims to evaluate the long-term outcomes of OTAP, addressing this gap in the medical literature.

NCT ID: NCT06110299 Not yet recruiting - Clinical trials for Ureteral Obstruction

Room Air a Safe Alternative to Dye Injection in Ureterography

Start date: October 29, 2023
Phase: N/A
Study type: Interventional

The procedure began in the Thirties .Retrograde pyelography is an essential step in most endoscopic procedure. This procedure is used as an investigation, with different indication in the past and the present, to delineate the ureter and pelvicalyceal system either before or after the operation, for example to detect any complication as a perforation and the need for stent placement. The procedure has an alternative, less invasive, the IVP. Multiple articles explored the use of air in the puncture of PCNL and to identify the posterior calyx, but to our knowledge there is no articles addressed the idea of air injection in the ureter. The greatest fear is air embolism or non-visualization of the ureter. The availability and cost of contrast material may be a problem, most urologist face

NCT ID: NCT06101563 Recruiting - Renal Stone Clinical Trials

Duration Between Drainage and Ureteroscopic Lithotripsy

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

This study will be conducted to compare early (one week) versus delayed (2-4 weeks) definitive ureteroscopic lithotripsy after initial drainage for obstructing ureteral or renal stones associated with infection.

NCT ID: NCT05992363 Not yet recruiting - Renal Failure Clinical Trials

Tandem Polyurethane Stents Compared to Single Silicone Stent for Malignant Ureteral Obstruction

TSTENT
Start date: October 2023
Phase: Phase 3
Study type: Interventional

Malignant ureteral obstruction (MUO) is an extrinsic ureteral obstruction caused by malignant diseases. This study aim to compare tandem 6 Fr Percuflex™ stents and single large-caliber 8Fr silicone stent in patients with MUO. The primary endpoint is stent failure rate. The secondary endpoints are patient comfort, quality of life and overall survival.

NCT ID: NCT05900375 Recruiting - Clinical trials for Ureteropelvic Junction Obstruction

Decision Aid for Parents of Infants With UPJO

Start date: January 21, 2023
Phase: N/A
Study type: Interventional

Ureteropelvic junction obstruction (UPJO) is the most common etiology of high-grade hydronephrosis, affecting approximately 4,000-10,000 infants annually in the U.S. The goal of surgical treatment of UPJO is to minimize the risk of kidney damage associated with obstruction, which may occur in 30-60% of infants with high-grade hydronephrosis.1-However, the benefit of early surgery compared to observation and potential later surgery to preserve kidney function has not been well-defined. Consequently, surgeons differ on whether to initially treat with surgery or observation, with surgical rates in the first year of life varying from 15-50% across surgical practices. These variations are important to understand, as the decision for early surgery is not without risk. Prior studies suggest that infants treated surgically are at higher risk for readmission and reoperation. Early surgery also raises concerns about neurodevelopmental effects of anesthetic exposure. To address this gap, the purpose of this pilot test is to develop a patient decision aid (PtDA) tool and pilot test its effect on parental understanding and engagement in the decision-making process at Children's Hospital Colorado. The proposed pilot is a necessary first step in preparation for a future multicenter hybrid effectiveness-implementation trial. This work will also be used to support future studies evaluating the impact of a PtDA on surgical variations and treatment outcomes in patients with UPJO and other complex congenital urologic anomalies.

NCT ID: NCT05895422 Recruiting - Clinical trials for Ureteropelvic Junction Obstruction

Functional Outcome After Minimally Invasive Pyeloplasty for Adult Patients With UPJO

Start date: June 1, 2023
Phase: Phase 3
Study type: Interventional

an intervention study on adult patients with uretero-pelvic junction obstruction (UPJO) due to crossing vessels would be managed either through classic dismembered pyeloplasty or vascular hitch.

NCT ID: NCT05858658 Completed - Child, Only Clinical Trials

Robot-Assisted Pyeloplasty in Young Children

PYEROB
Start date: November 1, 2022
Phase:
Study type: Observational

The goal of this retrospective study is to analyse the outcomes of Robot-Assisted Pyeloplasty in participants younger than 5 years old: - indication criteria - clinical symptoms - operating time - length of stay - complications - follow-up

NCT ID: NCT05640115 Recruiting - Cancer Clinical Trials

Obstruction of Malignancy: Percutaneous Renal vs Endoscopic Stent

Start date: September 22, 2023
Phase: Early Phase 1
Study type: Interventional

This research study will compare two procedures commonly used to treat urinary obstruction due to cancer. Sometimes cancer blocks one or both ureters (narrow tubes in the body that carry urine from the kidneys to the bladder). When these ureters become blocked, the body can no longer properly drain urine. This blocking of the ureters is called urinary obstruction, which can lead to kidney problems, infection, and pain. Treatment options for urinary obstruction include ureteral stent placement and percutaneous nephrostomy tube placement. Both treatment options require a doctor to place soft tubes (like a catheter) inside the body to help the ureters properly drain urine. These two treatment options have different success rates, risks, and effects on quality of life. By doing this study, researchers hope to learn which treatment option is best for individuals who develop urinary obstruction because of cancer. Participation in this research will last about 3 months.