Pruritus Clinical Trial
Background: Uremic pruritus is one of the common complications in long-term dialysis
patients. In general, many factors including xerosis, elevated serum calcium, phosphate,
calcium-phosphate product, hyperparathyroidism and inadequate dialysis may contribute to it.
Recently, researchers reported that immuno-hypothesis with high serum level of cytokines
could be the cause of uremic pruritus. Polymethylmethacrylate (PMMA) artificial kidney (AK)
has been reported to adsorb more serum cytokines than other high flux artificial kidneys.
Methods: In July 2006, 30 patients with severe uremic pruritus from 300 chronic hemodialysis
patients in a single center entered this prospective study. Their dialyzers were changed to
PMMA AK for 4 weeks. The severity of pruritus was evaluated every week using the results of
a questionnaire (pruritus score). Laboratory assays including pre-dialysis serum blood urea
nitrogen, creatinine, β2-microgblubulin (β2M), calcium, phosphate, intact parathyroid
hormone (iPTH), total CO2, ferritin, hematocrit, high sensitivity C-reactive protein
(hsCRP), IL-1, IL-2, IL-6, IL-18, TNF-α, KT/V and β2M clearance were measured before and at
the end of 4 weeks of PMMA AK use.
Expected Results:To prove the PMMA membrane could improve the uremic pruritus and to reveal
the effect of PMMA membrane on serum level of possible factors contributing to uremic
pruritus.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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