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TR1801-ADC in Patients With Tumors That Express c-Met

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial

Official title:
A Phase 1, Open Label, First-in-human Study of TR1801-ADC, an Antibody Drug Conjugate (ADC), in Patients With Select Solid Tumors Expressing c-Met

Clinical Trial Summary

First-in-human, Phase 1 study to assess safety, tolerability, and pharmacokinetics of TR1801-ADC in patients with select solid tumors that express c-Met.

Clinical Trial Description

First-in-human, Phase 1, multiple dose-dose escalation study designed to determine safety, tolerability, maximum tolerated dose, and recommended phase 2 dose of TR1801-ADC in patients with select solid tumors that express c-Met. This study will also assess pharmacokinetics (PK), anti-tumor activity, and correlation between clinical outcomes (safety, anti-tumor activity, and PK) and c-Met expression. ;

Study Design

Related Conditions & MeSH terms

  • Neoplasms
  • Unspecified Adult Solid Tumor, Protocol Specific
Clinical Trial Details
NCT number NCT03859752
Study type Interventional
Source Open Innovation Partners, Inc.
Contact
Status Suspended
Phase Phase 1
Start date August 14, 2019
Completion date December 31, 2023
View Details
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