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Clinical Trial Summary

To evaluate the efficacy and safety of Donafenib plus Sintilimab in combination with transarterial chemoembolisation (TACE) in patients with unresectable hepatocellular carcinoma(HCC).


Clinical Trial Description

Transarterial chemoembolisation (TACE) was effective and safe for hepatocellular carcinoma. Donafenib was better than sorafenib in overall survival in untreated advanced hepatocellular carcinoma, and programmed cell death protein-1 (PD-1) antibody was effective and tolerable in patients with advanced hepatocellular carcinoma. No study has evaluated TACE plus donafenib and sintilimab. Thus, the investigators carried out this prospective, single-arm study to find out it. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05507632
Study type Interventional
Source Nanfang Hospital of Southern Medical University
Contact Xiaoyun Hu
Phone 86-020-62787430
Email huxiaoyun143@163.com
Status Not yet recruiting
Phase Phase 2
Start date August 15, 2022
Completion date December 21, 2026

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