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Amitriptyline and Paroxetine Treatment of Major Depression

Unipolar Depression Clinical Trial

Official title:
Hypothalamus-pituitary-adrenal System: Role of the Mineralocorticoid Receptor and Longitudinal Study in Depressed Patients

Clinical Trial Summary

Activation of the hypothalamus-pituitary-adrenal system is monitored using saliva cortisol sampling during the antidepressant treatment with amitriptyline and paroxetine in moderately to severely depressed patients. Additionally, serum and plasma are sampled during the 5-week study period in order to study endocrine and metabolic parameters.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01049347
Study type Interventional
Source Central Institute of Mental Health, Mannheim
Contact
Status Completed
Phase Phase 3
Start date October 1997
Completion date May 2000
View Details
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