Ulcerative Colitis Clinical Trial
Official title:
A Magnetic Resonance Imaging (MRI) Study to Investigate Differences in the Structure and the Function of the Brain at Rest; Between Persons With Functional Pain Conditions Such as IBS or Vulvodynia, IBD and Healthy Controls
The structural/RSN study involves Structural and Resting State Neuroimaging. The purpose of
Structural Neuroimaging is to use MRI technology to identify cortical and white matter
morphometric differences between patients with chronic pain conditions and healthy control
subjects.
The purpose of the Resting State Neuroimaging study is to use functional MRI to identify
possible disease related differences in various resting state networks in the brain.
In addition we are looking at the effect gut microbiota on brain function in healthy and IBS
participants.
The overall goal is to identify structural and functional brain differences in persons with
chronic pain conditions such as Irritable Bowel Syndrome (IBS, Cyclical Vomiting
Syndrome(CVS) and vestibulodynia/vulvodynia. We are also looking at Inflammatory Bowel
Disease(ulcerative colitis and Crohn's disease. We will be comparing differences between
these conditions and matched healthy control subjects.
The study involves 2 visits. The screening visit is about 90 minutes and involves signing
the consent, completing questionnaires, a medical history, modified physical exam and
psychological interview to identify stressors, anxiety, depression and other conditions.
The second visit is the MRI visit (both functional and structural) and also will take about
90 minutes, with the scanning lasting about 45 minutes. There are questionnaires and a
measure of skin conductance also.
We have added a single stool sample for microbiota analysis and a food frequency
questionnaire in the healthy control and IBS populations.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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|---|---|---|---|
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