Type 2 Diabetes Clinical Trial
Official title:
Investigating the Protective Effect of Newer Antidiabetic Drugs on Cognitive Decline in Diabetic Patients
The proposed study aims to: 1. Explore the cognitive protective effects of SGLT2 inhibitors and DPP-4 inhibitors in patients attending diabetic clinics in Alexandria 2. Examine the possible relationship of such effects with the systemic inflammatory and metabolic status in these patients 3. Undertake a network analysis to elucidate the potential pathways linking the observed protective effects, if any, with the observed changes in inflammatory or metabolic parameters
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 2023 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years and older |
Eligibility | Inclusion Criteria: - Type 2 Diabetic Patients - Age (=50 Years) - Ability to understand and cooperate with study procedures Exclusion Criteria: - Diagnosed dementia - Use of possible or known cognition impairing drugs in the last three months |
Country | Name | City | State |
---|---|---|---|
Egypt | Alexandria University | Alexandria |
Lead Sponsor | Collaborator |
---|---|
Alexandria University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Reduced serum inflammatory markers in intervention group | 1 Year | ||
Primary | Prevention of decline in cognitive function associated with type 2 diabetes | Slowed reduction of the Montreal Cognitive Assessment Battery Score | 1 Year | |
Secondary | Better cognitive performance in the intervention group at baseline | Higher Montreal Cognitive Assessment Battery Score | 1 Year |
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