Cognitive Protective Effect of Newer Antidiabetic Drugs

Status Recruiting

Clinical Trial Summary

The proposed study aims to: 1. Explore the cognitive protective effects of SGLT2 inhibitors and DPP-4 inhibitors in patients attending diabetic clinics in Alexandria 2. Examine the possible relationship of such effects with the systemic inflammatory and metabolic status in these patients 3. Undertake a network analysis to elucidate the potential pathways linking the observed protective effects, if any, with the observed changes in inflammatory or metabolic parameters

Clinical Trial Description

The investigators propose to profile diabetic patients taking SGLT2 inhibitors and DPP-4 inhibitors using different parameters and compare them to others on more traditional anti-diabetic therapy. Regression and comparative statistics will be used to determine whether the targeted drug classes offer a benefit in terms of cognitive function. If a trend (or correlation) is determined, a bioinformatic approach will be adopted to perform a network analysis including the targets of these drug classes and pathways showing in datasets of the inflammatory or metabolic parameters altered by the drug. This network analysis is intended to provide further mechanistic insight into the pathways involved in the observed drug action. The patients targeted will be divided into the following groups: 1. Diabetic patients treated with metformin and DPP-4 inhibitors and/or SGLT2 inhibitors 2. Diabetic patients treated with metformin only This will be in addition to a group of healthy non-diabetic controls to serve as a baseline reference. ;

Study Design

Related Conditions & MeSH terms

Type 2 Diabetes

Clinical Trial Details

NCT number	NCT05347459
Study type	Observational
Source	Alexandria University
Contact	Shams T Osman, BPharm
Phone	+201096900070
Email	s-shams.mostafa@alexu.edu.eg
Status	Recruiting
Phase
Start date	March 2, 2022
Completion date	December 2023

View Details

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