Type 2 Diabetes Clinical Trial
Official title:
Obstructive Sleep Apnea and Aspirin Resistance in Type-2 Diabetic Patients
Type-2 Diabetes and Sleep Apnea Syndrome (SAS) are both related to an increase in platelet
activation. Type 2 diabetes is often associated with sleep apnea syndrome with a prevalence
up to 60%.
The main objective of our study is to analyze the influence of sleep apnea on the response to
antiplatelet therapy in stable aspirin-treated type-2 diabetes patients.
Consecutive stable aspirin-treated type-2 diabetes patients referred for suspicion of sleep
apnea will be recruited after providing informed consent. Response to aspirin will be
assessed with the Verify Now Aspirin(TM)rapid analyser in the morning after nocturnal
polysomnography, and compared with a group of type-2 diabetes free of sleep apnea. Other
endocrine, metabolic, hematologic and cardiovascular confounders will also be assessed at
baseline to determine their influence on the response to aspirin.
Then, Patients with severe SAS (Apnea-Hypopnea Index> 30 events/h) and response with Aspirin
(ARU > 454) will be randomized to 3 months of active or sham continuous positive airway
pressure treatment in a pilot study. After the 3-months of intervention, response to aspirin
will be compared between the sham and effective CPAP groups.
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