Type 2 Diabetes Clinical Trial
Official title:
The Extrapancreatic Metabolic Effects of Incretin Hormones
Incretin hormones (GLP-1 and GIP) have insulin secretory effects on the pancreas that are
glucose dependent. Extrapancreatic effects of incretin hormones are reported, however the
glucose dependency of these effects have not been examined. In type 2 diabetes, pancreatic
endocrine function and incretin metabolism are impaired. The investigators hypothesize that
extrapancreatic effects of incretin hormones are glucose depedent and dysregulated in
subjects with type 2 diabetes.
Healthy control subjects and type 2 diabetics will undergo pancreatic clamps. In brief,
somatostatin will be infused to inhibit pancreatic endocrine function and basal levels of
insulin, glucagon, and growth hormone will be replace via infusion. Metabolic flux will be
studied during euglycemic and hyperglycemic stages of the pancreatic clamp. Each subject
will undergo 3 trials involving the co-infusion of either saline(Control Trial), GLP-1, or
GIP. Glucose metabolism will be assessed using 13C-glucose stable isotope methodology
combined with indirect calorimetry and expired breath isotope ratio analysis. Blood flow and
flow-mediated dilation will be measured using ultrasound Doppler. Skeletal muscle and
abdominal adipose biopsies will be taken to examine intracellular signalling.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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