Is Carotid Intima-media Thickness Affected by A1C Variability?

Type 2 Diabetes Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00842972
• Other study ID #: 3-2006-0005
• Status: Completed
• Phase: N/A
• First received: February 11, 2009
• Last updated: September 14, 2009

Study information

• Verified date: September 2009
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 34 Years to 79 Years

Eligibility

Inclusion Criteria:

• type II

• fluoroscopy in carotid once a year during 2 years

Exclusion Criteria:

• type 1 diabetes

• history or clinical evidence of coronary artery disease or cerebral or peripheral vascular disease

• the presence of albuminuria (defined as 24 hour urine albumin excretion = 30 mg)

• renal dysfunction (defined as creatinine blood level = 2.0 mg/dL)

• hepatic dysfunction (defined as alanine aminotransferase and/or aspartate aminotransferase blood level = 3 × upper normal limit)

• smoking within the past 3 months prior to commencement of the study

• use of any medication likely to alter IMT such as calcium channel blocker, thiazolidinedione, antiplatelet agent (clopidogrel, cilostazol)

• use of glucocorticoid

• pregnancy

• severe concomitant disease such as cancer

• infection

• Cushing's syndrome

• acromegaly, or any other disorder likely to alter glycemia

• primary hypercholesterolemia

• hypothyroidism or hyperthyroidism

• use of any hormonal drugs

• alcoholism or drug abuse

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• A1C Variability
• Type 2 Diabetes

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University