Short-term Effect of Intensive Insulin Therapy on Incretin Secretion

Status Completed

Clinical Trial Summary

In type 2 diabetic patients, abnormality in secretion or action of incretin(GLP-1, GIP) is observed. Although controversy still exists, the secretion of GLP-1 is thought to be reduced by 20-30% while GIP secretion is normal or slightly elevated, in type 2 diabetic patients. Various parameters such as the duration of diabetes, the amount of meal and their constitution, gastric bypass surgery, and some antidiabetic drugs affect the secretion of incretin. However, the secretion of GLP-1 and GIP in glucotoxic condition and whether they recover after improvement of glycemic status is not known. The investigators aim to study the effect of intensive insulin treatment in uncontrolled diabetic patients.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Type 2 Diabetes

Clinical Trial Details

NCT number	NCT00776243
Study type	Observational
Source	The Catholic University of Korea
Contact
Status	Completed
Phase	N/A
Start date	October 2008
Completion date	December 2009

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