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Clinical Trial Summary

Alpha-melanocyte stimulatory hormone (α-MSH) is a melanocyte-stimulating hormone produced by the hypothalamus and released from the pituitary gland. It acts as an agonist to the melanocortin 5 receptor (MC5R) in human skeletal muscle, playing a role in glucose uptake and disposal. This study aims to investigate whether α-MSH can enhance glucose tolerance in patients with Type 2 Diabetes Mellitus (T2DM).


Clinical Trial Description

Pre-clinical studies in mice have shown improved glucose clearance with α-MSH infusion, particularly in skeletal muscle. Research has demonstrated that α-MSH improves glucose tolerance in healthy humans by promoting glucose uptake in skeletal muscle cells. Therefore this study seeks to answer the question of whether alpha-MSH improves glucose tolerance in patients with T2DM. This will be addressed through measuring the impact of α-MSH infusion in patients with T2DM. The research involves a double-blinded, randomized, placebo-controlled crossover study. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06293664
Study type Interventional
Source Dasman Diabetes Institute
Contact Ebaa Al Ozairi, MD
Phone (+965) 22242999
Email ebaa.alozairi@dasmaninstitute.org
Status Recruiting
Phase N/A
Start date March 4, 2024
Completion date April 4, 2024

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