Type 2 Diabetes Mellitus Clinical Trial
Official title:
Rationale and Design of a Simple Randomized Trial Evaluating Losartan and Perindopril in Blacks Type 2 Diabetics Patients: the Cardiac and Renal Protection With Losartan or Perindopril (CARE-PLP) Trial
The aim of this study is to compare the short-term effects of ACEi and angiotensin II receptor blockers on cardiac and renal protection in black type 2 diabetics patients CARE-PLP is a double-arm, double-blind, randomized and parallel clinical trial conducted at the National Obesity Center in the Yaoundé Central Hospital. A population of Type 2 diabetes patients, with hypertension and / or microalbuminuria and who are not taking ACEi or angiotensin receptors blockers, is randomize into two groups. Depending on the group, 10 mg Perindopril or 100 mg Losartan is add to the usual treatment for each patient. The patients are followed-up for a period of 08 weeks. The primary outcome is the variation of exercise induced urinary albumin excretion after 08 weeks of intervention.
Given the particularity of the renin-angiotensin system in black subjects, the CARE-PLP study
fulfills this objective with the comparison of Losartan and Perindopril after 08 weeks of
administration in a subsaharan African population.
Aim: The aim of this study is to compare the short-term effects of ACEi and angiotensin II
receptor blockers on cardiac and renal protection in black type 2 diabetics patients
Methods: CARE-PLP is a double-arm, double-blind, randomized and parallel clinical trial
conducted at the National Obesity Center in the Yaoundé Central Hospital. A population of
Type 2 diabetes patients, with hypertension and / or microalbuminuria and who are not taking
ACEi or angiotensin receptors blockers, is randomize into two groups. Depending on the group,
10 mg Perindopril or 100 mg Losartan is add to the usual treatment for each patient. The
patients are followed-up for a period of 08 weeks. The primary outcome is the variation of
exercise induced urinary albumin excretion after 08 weeks of intervention.
Progress: Recruitment for CARE-PLP was completed in february 2018 with 29 patients.
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