Type 2 Diabetes Mellitus Clinical Trial
Official title:
Does Daily Ischaemic Preconditioning Improve Blood Vessel Function and Insulin Sensitivity in Type 2 Diabetes Mellitus?
The aim of this study is to determine the impact of 7 days of daily ischemic preconditioning (IPC) on vascular function and insulin sensitivity in Type 2 Diabetes Mellitus.
Occlusion (cuff inflation to a pressure that reduces blood flow) using a blood pressure cuff
on the upper arm for 5 mins followed by recovery (cuff deflation so blood flows normally
gain), is known as ischemic preconditioning (IPC). An intervention consisting of 4 cycles of
5 min arm occlusion followed by 5 min periods of recovery on a daily basis can improve blood
vessel function. This is a simple and easily applicable intervention that immediately
improves the blood vessels capacity to deliver blood to an organ (e.g. heart or the muscle).
However, it is currently unknown if a daily IPC can improve blood vessel function in patients
with type 2 diabetes mellitus (T2DM) and if it will aid in improving blood glucose control.
Therefore, the purpose of this study is to investigate if daily IPC for 7 days can improve
blood vessel function and blood glucose control in T2DM.
This randomised control trial consists of 3 visits to Liverpool John Moores University;
before intervention, immediately following intervention, and 8 days following the end of the
intervention. Participants will be trained to apply the IPC device and then perform it at
home daily for 7 days.
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