Type 2 Diabetes Mellitus Clinical Trial
Official title:
A Double-blinded, Randomised, Four-period Crossover Euglycemic Clamp Trial Investigating the Dose-linearity of BioChaperone® Combo 75/25 and the Safety at Three Different Doses in Subjects With Type 2 Diabetes
This is a bicentric, double-blinded, randomised, four-period crossover phase 1 trial, using automated 30-hour euglycemic clamp in subjects with type 2 diabetes mellitus.
This is a bicentric, double-blinded, randomised, four-period crossover phase 1 trial, using
automated 30-hour euglycemic clamp in subjects with type 2 diabetes mellitus.
Each subject will be randomly allocated to a sequence of four treatments, three single doses
of BioChaperone® Combo 75/25 (0.6 U/kg, 0.8 U/kg or 1.0 U/kg) and one single dose of Humalog®
Mix25 at 0.8 U/kg on four separate dosing visits.
Subjects will come in a fasted state to the clinical trial centre in the morning of each
dosing day and stay at the clinical trial centre until the 30-hour clamp procedures have been
terminated.
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