Type 2 Diabetes Mellitus Clinical Trial
Official title:
Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients
This study evaluates the more suitable treatment for the prevention of vascular complications in diabetes patents who were at high cardiovascular risk group by comparing the platelet aggregation inhibitory effect of aspirin and cilostazol.
Diabetes is a dangerous disease with high risk of vascular complications. Thus, to prevent
these vascular complication, antithrombotic drug may be administered. Representative
antithrombotic agents are aspirin and cilostazol. However, recent studies suggested that
aspirin did not have sufficient effect to prevent vascular complications of diabetes. For
that reason, it have been reported that antithrombotic effects of aspirin were falling in
diabetes patients, so-called 'aspirin resistance.
On the other hand, cilostazol used as the control drug inhibits atherosclerosis in diabetes
patients in the studies of Asia including Korea, and it is effective to inhibit the risk of
various cardiovascular disease. Therefore, cilostazol is likely to use drugs as substitute
for aspirin therapy.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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