Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT02542059 |
| Other study ID # |
NL51058.091.14 |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
August 2015 |
| Est. completion date |
July 2024 |
Study information
| Verified date |
November 2023 |
| Source |
Radboud University Medical Center |
| Contact |
Marti Boss, Msc |
| Phone |
+31-24-36 |
| Email |
marti.boss[@]radboudumc.nl |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
In order to evaluate the difference in beta cell mass in patients with and without complete
resolution of type 2 diabetes mellitus (T2DM) after Roux en Y gastric bypass (RYGB)
investigators aim to compare quantitative PET imaging of the pancreas between these patient
groups.
These highly relevant data will provide investigators with more information on the possible
role of beta cell mass in the mechanisms behind resolution of T2DM after bariatric surgery.
This would be of great interest for the assessment of RYGB as an alternative therapy in
patients with T2DM with a BMI <35, who currently do not meet the international guidelines for
bariatric surgery.
Description:
Obesity and T2DM The prevalence of Type 2 Diabetes Mellitus (T2D) in the Netherlands is
600.000-800.000 and each year ~70.000 new patients are diagnosed. This increasing number of
patients with T2D is closely correlated with the obesity epidemic. In women, over 50% of T2D
risk can be accounted for by obesity. Also, over 85% of T2D patients are overweight and ~50%
are obese.
Obese patients with T2D not only have elevated glucose levels but are also at risk to develop
dyslipidemia and hypertension. This clustering of cardiovascular risk factors leads to an
increased risk of micro-and macrovascular long-term complications. In fact, patients with T2D
have a 2-4 times increased risk for cardiovascular disease. These complications seriously
decrease the quality of life and life expectancy of T2D patients. The burden of this disease
not only affects these patients but our society as well. Health care costs with respect to
diabetes amounted 814 million euro in 2005 in the Netherlands and indirect costs because of
absence of work are unknown but thought to be substantial.
Weight loss is perhaps the most important therapeutic intervention in obese patients with
T2D. Weight loss intervenes in the underlying pathophysiology and restores insulin
sensitivity and sometimes even insulin secretion. In addition, it improves dyslipidemia and
hypertension. In contrast, most pharmacological interventions only relieve the symptoms of
the complex disease process underlying T2DM whilst the disease process itself is not
addressed and even progresses in the course of time. Unfortunately, the effect of weight loss
interventions such as diet and lifestyle or even drugs is often modest (3-5 kg) and
short-lived.
Bariatric surgery and T2DM remission Weight reducing surgery, i.e. bariatric surgery, is the
only intervention that leads to persistent weight loss and it is superior above conventional
(non-surgical) treatment.
Bariatric surgery can be divided into restrictive (gastric band) and malabsorptive procedures
(biliopancreatic diversion) or a combination of the 2 (Roux-en-Y Gastric Bypass, RYGB).
The current indications are BMI > 40 kg/m2 or BMI > 35 kg/m2 with co-morbidities like T2D.
The greater the malabsorptive component, the greater the effect on weight loss.
Meta-analyses also showed spectacular metabolic improvement of bariatric surgery in obese
patients with T2D.
The mechanism of diabetes resolution after RYGB is not completely understood and there is
evidence that it might not be completely dependent on weight loss. While significant weight
loss has not yet been achieved within days after the surgery, glycemic control has been found
to occur already at this time. Also, the improvement in glucose control after gastric bypass
is greater than with equivalent weight loss obtained by dietary intervention or purely
restrictive bariatric procedures. There are several hypotheses concerning the
weight-independent effects of bariatric surgery on insulin secretion. The most popular ones
are the 'hindgut-hypothesis', which states that expedited delivery of nutrients to the distal
intestine enhances the secretion of intestinal peptides like glucagon-like-peptide 1 (GLP1)
and peptide YY and the 'foregut hypothesis', which states that the exclusion of the duodenum
and proximal jejunum from the transit of nutrients results in changes in secretion of
intestinal peptides. However, several other mechanisms, both in- and outside the intestines
might play a role.
While improvement of beta cell function has been reported in both healthy individuals as well
as T2D patients after RYGB it is unclear whether the actual beta cell mass is subject to
change after bariatric surgery. In Goto-Kakizaki rats duodenal jejunal bypass was found to
increase pancreatic concentrations of vesicular monoamine transporter type 2 (VMAT2), a
biomarker for beta cells. Furthermore, an increase in beta cell mass, beta cell number and
extra islet beta cells was found after RYGB in a porcine model. However, there are only few
studies in humans, with conflicting results.
The benefit of bariatric surgery on glycemic control in morbidly obese patients (BMI 35 kg/m2
or more) with T2DM is confirmed and has been accepted as an alternative therapy in this
patient population for treatment of T2DM by the Diabetes Surgery Summit Consensus Conference
(DSS), which was participated by 50 experts and endorsed by multiple international scientific
societies (such as American Diabetes Association (ADA) and the International Federation for
the Surgery of Obesity and Metabolic diseases (IFSO)) and the International Diabetes
Federation Taskforce on epidemioloy and Prevention of Diabetes, a consensus working group of
diabetologists, surgeons and public health experts. They also consider expanding the
indications for bariatric surgery in obese patients with T2D who currently don't meet the
international guidelines for bariatric surgery. In this regard, more information on the
effects of bariatric surgery on beta cell function and beta cell mass would be helpful. If
this information could be obtained preoperatively this would improve the selection of
patients who would benefit from bariatric surgery.
Imaging of beta cells in vivo Reliable, sensitive and specific visualization of living
pancreatic beta cells in vivo is important to broaden our understanding of resolution of T2D
after bariatric surgery. Reliable quantification of the remaining beta cell mass will lead to
a better assessment of beta cell function after bariatric surgery. This could lead to a
better understanding of the relative importance of factors leading to the recovery of
glycemic control. This could help in the consideration whether to expand the indications for
bariatric surgery to patients with T2D who currently do not meet the criteria (BMI<35).
