Type 2 Diabetes Mellitus Clinical Trial
Official title:
The Impact of Dietary Nitrate Supplementation on Exercise-induced Cardiac Troponin T Release in Type 2 Diabetic Patients
Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac
injury. Previous research has shown that type 2 diabetic patients may experience large
increments in cTnT levels over the subsequent hours following a single bout of
moderate-intensity endurance-type exercise. This phenomenon is likely attributed to cardiac
ischemia-reperfusion injury caused by reduced nitric oxide (NO) bioavailability. Recent
evidence indicates that ingestion of dietary nitrates dramatically increases the
bioavailability of NO, and as such, may be protective against cardiac ischemia-reperfusion
injury.
The investigators hypothesize that dietary nitrate supplementation blunts the rise in cTnT
levels following exercise in type 2 diabetic patients.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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