Type 2 Diabetes Mellitus Clinical Trial
Official title:
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
The potential clinical implications of this study are to optimise the selection of a
population at risk for developing a diabetic cardiomyopathy among diabetic patients in order
to develop early therapeutic strategies to prevent the left ventricular remodelling.
Therefore, the originality of this project is to hypothesize that :
- Diabetes mellitus is often associated with a premature aging syndrome
- Cellular senescence may potentiate the mechanisms that are involved in decreasing
myocardial contractility in DM and,
- DM associated to premature aging may increase the risk of developing a cardiomyopathy
Thus, the modulation of telomerase activity and the control of telomere length, together
with the attenuation of the formation of reactive oxygen species, might represent
important new targets in order to develop therapeutic tools in prevention of diabetic
cardiomyopathy.
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