Type 2 Diabetes Mellitus Clinical Trial
Official title:
Interactions Between Exogenous Insulin Aspart, Endogenous Insulin and Plasma Glucose in Type 2 Diabetes Mellitus Patients
This is an exploratory trial with two cross-over arms investigating pharmacokinetic profiles
of endogenous and exogenous insulin in type 2 diabetes mellitus patients treated with
continuous subcutaneous Insulin Aspart infusion and combined with or without intravenous
glucose infusion. The order of treatment session will be randomised.
Hypotheses:
1. Secretion of endogenous insulin depends on exogenous insulin supply
2. Secretion of endogenous insulin is depends on plasma glucose levels
There are a screening visit and two treatment sessions:
Session A: Treatment with Insulin Aspart 1.5 IE/time overnight without intravenous glucose
infusion Session B: Treatment with Insulin Aspart 1.5 IE/time overnight with intravenous
glucose infusion.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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