Type 2 Diabetes Mellitus Clinical Trial
Official title:
Effect of Urtica Dioica on Glycemic Control in Patients With Type 2 Diabetes Mellitus
Diabetes mellitus is the most common metabolic disorder worldwide. Some herbs are
traditionally used in treatment of type 2 diabetes mellitus (T2DM). Urtica Dioica (UD) or
stinging nettle is traditionally used in Morocco, Turkey, Brasil, Jordan and with much
frequency in northern Iran.
Studies on animal models along with in vitro studies has shown hypoglycemic effect for
aqueous extract of UD.
This study aimed to investigate hypoglycemic effects of UD tea bags in patients with T2DM on
glycemic control, insulin sensitivity, along with its effects on lipid profile (LP), blood
pressure (BP), liver, and kidney function.
The study will be performed under randomized, double-blind, placebo controlled, and
case-control design. The object of this study is patients with T2DM. Patients are randomly
assigned to start with placebo tea bags (3 tea bags as 2-gram tea bag steamed in boiling
water for 20 minutes: mixture of bran powder which is already boiled in water twice plus
spinach powder) in control groups and UD tea bags (3 tea bags as 2-gram tea bag steamed in
boiling water for 20 minutes) in patients with T2DM for two months. Every two weeks, fasting
glucose, postprandial glucose after a standard breakfast, serum insulin, lipids, alanine
amino transferase (ALT), aspartate amino transferase (AST), creatinine (to calculate GFR),
along with blood pressure will be measured.
To the best of our knowledge, this is the first Randomized Clinical Trial.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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