Type 1 Diabetes, Sleep Apnea Syndrome Clinical Trial
Official title:
Sleep Apnea in Type 1 Diabetes : Prevalence, Role of Glycemic Control and Autonomic Neuropathy
Sleep apnea syndrome is strongly associated to type 2 diabet, partly and this is partly due to obesity. Treatment of sleep apnea may improve hypertension, cardiovascular risk and in some studies diabetes status. Few data are available for type 1 diabetes but suggest that the prevalence of sleep apnea syndrome may be high. We plan to compare the prevalence of sleep apnea syndrome assessed by polysomnography in a sample of type 1 diabetic patients and a control group matched by age, gender and body mass index. The secondary objective is to determine if the presence of an autonomic neuropathy or poorly controlled diabetes (assessed by glycosylated haemoglobin) may or not contribute to the presence of sleep apnea in the diabetic group.
Diagnostic protocol designed to evaluate if if sleep apnea syndrome is more frequent in type
1 diabetes than in general population and therefore deserves to be more systematically
suspected and actively diagnosed in this patients. Sleep apnea syndrome is a heavy burden as
a matter of quality of life: it is responsible for fatigue, diurnal sleepiness, cognitive
impairment, poor and /or non restorative sleep, morning headaches, depressive mood…Adequate
treatment provides a rapid and, most of the time, complete relief of these symptoms.
On an other hand, Sleep Apnea is and independent risk factor for cardiovascular mortality and
morbidity in young and middle aged subjects, also reversed by treatment. It might be
therefore important for type 1 diabetic patients who have already an increased cardiovascular
risk to be properly diagnosed for sleep apnea. A systematic screening for sleep apnea is
already recommended for patients with type 2 diabetes by experts.
A secondary objective is to determine if the presence of a sleep apnea syndrome in type 1
diabetic patients is associated to an autonomic neuropathy, a poor glycemic control , a
poorer quality of life , a poorer quality of sleep, more severe cardiovascular consequences
and biological impairment.
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