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A Pan-TB Regimen Targeting Host and Microbe — panTB-HM  

Tuberculosis Clinical Trial

Official title:
A Novel 4-month Pan-TB Regimen Targeting Both Host and Microbe (panTB-HM)

Clinical Trial Summary

This project will develop the first regimen meeting WHO criteria for a pan-TB indication, ie, not requiring knowledge of RIF susceptibility. The regimen will test sutezolid at 2 dose levels, with the approved anti-TB drugs bedaquiline and pretomanid, in a phase 2c trial. It will also test whether the addition of N-acetylcysteine (NAC), a re-purposed host-directed WHO essential medicine, can protect the lung and liver against oxidative damage, preserve lung function, and accelerate the eradication of MTB infection by replenishing glutathione (GSH).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05686356
Study type Interventional
Source The Aurum Institute NPC
Contact Professor Robert Wallis
Phone +1 (860) 271-6745
Email rwallis@auruminstitute.org
Status Recruiting
Phase Phase 2/Phase 3
Start date July 28, 2023
Completion date September 30, 2025
View Details
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