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Clinical Trial Summary

1. The primary objective is to improve the sensitivity of novel immunodiagnostic tests for detection of TB disease in children. 2. The secondary objective is to determine biomarkers that discriminate children with TB infection and disease.


Clinical Trial Description

1. This will be done by measuring a variety of parameters in the blood samples and compare them with the current diagnostic gold standard for TB or for culture/NAAT non-confirmed TB cases a consensus case definition is used. Currently available immunodiagnostic tests (IGRA/TST) will be compared to novel immunodiagnostic tests which will include: - several novel, additional M. tuberculosis-specific Antigens - cytokines that are highly expressed 2. Since there is no diagnostic gold standard for TB infection we will rely on a clinical composite reference standard for diagnosing TB infection. Biomarkers will be determined by: - including M. tuberculosis-specific antigens that are specifically expressed in either TB infection or disease, - measuring phenotypes and cytokine production of M. tuberculosis-specific cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03044509
Study type Observational [Patient Registry]
Source University Children's Hospital Basel
Contact Nora Fritschi, Dr med
Phone +41617042947
Email nora.fritschi@ukbb.ch
Status Recruiting
Phase
Start date May 12, 2017
Completion date December 2022

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