Tuberculosis Clinical Trial
Official title:
Diagnostic Accuracy of Different Bronchoscopic Sampling Techniques in Patients With Mediastinal Lymph Node Enlargement Suspected of Sarcoidosis
The development of endobronchial ultrasound (EBUS) and EBUS-guided transbronchial needle
aspiration (EBUS-TBNA) has improved the safety and diagnostic accuracy of the mediastinal
lymph node (MLN) sampling. Still, in some diseases routine cytological specimens are
considered insufficient and histological sampling is preferred. The aim of the study is to
compare the diagnostic accuracy of EBUS-TBNA and two other, more invasive procedures to
obtain histological samples from MLN in patients with clinical and radiological features of
sarcoidosis.
Bronchoscopy with bronchoalveolar lavage (BAL), EBUS-TBNA, EBUS guided transbronchial
forceps biopsy (EBUS-TBFB), large bore (19G) histology TBNA as well as endobronchial forceps
biopsy will be performed in 90 consecutive patients with mediastinal lymph node enlargement
and clinical and radiological features of sarcoidosis.
Diagnostic accuracy of each sampling technique will be calculated and compared to other
techniques. Diagnostic yield of different technique combinations will also be calculated and
the most efficient diagnostic approach will be defined.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
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