Tuberculosis Clinical Trial
Official title:
Measurement of Human T−Cell Turnover Following Vaccination With the Tuberculosis Vaccine MVA85A
This study examines the early immune response to a new vaccine (MVA85A) being developed to combat tuberculosis (TB).
MVA85A is a promising new vaccine designed to prevent tuberculosis (TB) by dramatically
boosting pre-existing responses to BCG, the only licensed vaccine against the disease at
present. In BCG vaccinated individuals it induces a strong immune response. However little
is known about the evolution of that response or of the kinetics of T-cells (the immune
cells that respond to the vaccine) immediately following vaccination. Crucially, the outcome
of this process may determine long term protection from disease.
This study aims to define the early immune response to MVA85A and is the first to apply a
safe, non-radioactive 'label' - deuterium - to measure T-cell turnover following
vaccination. This labelling approach has been used successfully by the study collaborators
to examine immune cell kinetics in human clinical studies in the UK over the last 8 years.
The resulting data will provide insight into the immune response generated by MVA85A and aid
in the future design and modification of other T-cell inducing vaccines.
Group 1 (Immune responses only)
Previous human studies of MVA85A have described the immune response to vaccination at fixed
timepoints but not in between. The investigators will vaccinate four volunteers and measure
immune responses daily for 14 days. This will provide important new data and aid
interpretation of kinetics data from groups 2 and 3.
Groups 2 & 3 (Labelling)
Eight volunteers will be vaccinated and then receive a timed infusion of deuterated glucose.
Blood will be collected during the follow up period to determine the rates of uptake and
loss of label in responding immune cells.
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Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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