Tuberculosis Clinical Trial
Official title:
Tuberculosis Immunity in Children
Verified date | January 2008 |
Source | National Institute of Allergy and Infectious Diseases (NIAID) |
Contact | n/a |
Is FDA regulated | No |
Health authority | Unspecified |
Study type | Observational |
The purpose of this study is to gain a better understanding of how immunity to tuberculosis (TB) is maintained in children. When children get tuberculosis, it is more likely to spread to other parts of the body than when adults get it. This study will compare the blood cells that fight TB in children to the blood cells that fight TB in adults. Children enrolled in this study will have blood drawn on 1 or 2 occasions. Adult participants will be leukapheresed, a process in which blood passes through a machine collecting specific blood cells and returning the remaining blood to the body. An estimated 260 subjects will be enrolled in this study.
Status | Completed |
Enrollment | 260 |
Est. completion date | April 2010 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: Children: - Diagnosed with latent Mtb infection (LTBI), localized tuberculosis (TB), or disseminated TB. - Age less than or equal to 10 years. Adults: - Diagnosed with localized TB or LTBI. - All individuals with LTBI will be healthy. - Individuals with localized TB will have been treated for TB for at least 1 month. Exclusion Criteria: - Older children 11-17 years old. - Children who are immunocompromised. - Immunocompromised adults. - Pregnant women. - Non-English or non-Spanish speaking individuals. |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Oregon Health Sciences University | Portland | Oregon |
Lead Sponsor | Collaborator |
---|---|
National Institute of Allergy and Infectious Diseases (NIAID) |
United States,
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