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Trigeminal Neuralgia clinical trials

View clinical trials related to Trigeminal Neuralgia.

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NCT ID: NCT06315790 Recruiting - Clinical trials for Trigeminal Neuralgia

Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia

Start date: November 1, 2023
Phase: Phase 3
Study type: Interventional

This is a double-blind randomized clinical trial comparing the pain reduction of individuals treated with BTX-A and placebo as well as evaluating possible changes in neuroinflammatory biomarkers. The trial lasts 16 weeks, with a 4-week baseline phase and a 12-week randomization phase. Four visits are planned: 1) Introduction and baseline data collection, 2) Medical evaluation and treatment assignment, 3) Follow-up with biomarker analysis, and 4) Trial conclusion interview. 80 participants will be included and randomized 1:1.

NCT ID: NCT06278194 Not yet recruiting - Clinical trials for Trigeminal Neuralgia

Masseter Muscle Thickness in Gasser Ganglion Radiofrequency Treatment

Start date: March 15, 2024
Phase: N/A
Study type: Interventional

Trigeminal neuralgia is common painful disorder in pain medicine clinics. Gasserian ganglion radiofrequency thermocoagulation is one of the treatment option in patients with trigeminal neuralgia in refractory cases. The most commonly involved branch in trigeminal neuralgia is the mandibular branch. Masseter muscle is innervated by mandibulary nerve branch of the trigeminal nerve. The radiofrequency thermocoagulation therapy is used to ablate the affected trigeminal nerve branch and some of patients complain of subjective masseter weakness after this procedure. In theoretical basis, muscles innervated by target nerve are affected from ablation procedure. In this study the primary aim is to evaluate the change of the masseter muscle thickness in patients treated by gasserian ganglion radiofrequency thermocoagulation. The results may also show possible functional effect of the procedure related with masseter muscle.

NCT ID: NCT06240494 Completed - Clinical trials for Trigeminal Neuralgia

Predictive Factors in Maxillary and Mandibular Nerve Radiofrequency Treatment for Trigeminal Neuralgia

Start date: January 1, 2023
Phase:
Study type: Observational

Trigeminal neuralgia is one of the most common craniofacial neuralgias and one of the most severe types of facial pain, typically limited to the distribution of the trigeminal nerve. The first-line treatment for trigeminal neuralgia is medical therapy and primarily antiepileptic drugs. Various interventional and surgical methods can be used in patients who do not respond to medical treatment or who cannot tolerate side effects. Pulsed radiofrequency treatment of maxillary and mandibular nerves may provide longer-lasting pain relief in trigeminal neuralgia.This study aimed to investigate the clinical and demographic characteristics affecting treatment success in patients who underwent ultrasound-guided pulsed radiofrequency of the maxillary and/or mandibular nerves for trigeminal neuralgia.

NCT ID: NCT06216886 Not yet recruiting - Clinical trials for Trigeminal Neuralgia

OnabotulinumtoxinA for Trigeminal Neuralgia

Start date: February 1, 2024
Phase: Phase 4
Study type: Interventional

A randomized controlled trial comparing Onabotulinumtoxin A to saline (placebo) for Trigeminal Neuralgia.

NCT ID: NCT06213155 Recruiting - Clinical trials for Trigeminal Neuralgia

A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adults With Trigeminal Neuralgia

CryoGem
Start date: January 2024
Phase: N/A
Study type: Interventional

The CryoGem Trial is a research study that tests a freezing technique called cryoneurolysis to see if it helps relieve pain in adults with trigeminal neuralgia. Trigeminal neuralgia is a condition that causes severe facial pain. In this study, we want to find out if the freezing technique is effective and safe. We will do this by comparing two groups of adults with trigeminal neuralgia. One group will receive the actual treatment, while the other group will receive a fake treatment called a sham. Neither the participants nor the assessors will know which group they are in (this is called a blinded study). For the next four weeks, participants in both groups will continue recording their headaches without knowing which treatment they are receiving. After this initial period, there will be an extension period where all participants can receive treatment as needed for up to two years. The results of this study will help us decide if the freezing technique is a viable treatment option for trigeminal neuralgia. Our main goal is to see how many people in each group have a significant reduction in pain (at least 75% less pain). We will also record other important information about the participants. We are looking to recruit up to 24 adults with trigeminal neuralgia to take part in this study. All participants will keep a daily diary for two weeks to track their headaches before starting the treatment. Then, they will be randomly assigned to either the treatment group or the sham group.

NCT ID: NCT06174818 Completed - Clinical trials for Trigeminal Neuralgia (TN)

Pulsed Radiofrequency Treatment Of the Gasserian Ganglion for tRigeminal nEuralgia: a retroSpective Study

Progress
Start date: April 17, 2022
Phase:
Study type: Observational

With the Pulsed Radiofrequency treatment (PRF) Of the Gasserian ganglion for tRigeminal nEuralgia: a retroSpective Study (PROGRESS) the objective is to document the outcome of PRF (Pulsed Radiofrequency treatment) for patients with TN (Trigeminal Neuralgia), unresponsive to conservative treatment.

NCT ID: NCT06129071 Not yet recruiting - Clinical trials for Trigeminal Neuralgia

Analgesic Effect of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

This is a study about the dynamics and effects of ultrasound guided maxillary nerve block in trigeminal neuralgia

NCT ID: NCT06019338 Completed - Clinical trials for Trigeminal Neuralgia

A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia

Start date: November 20, 2021
Phase:
Study type: Observational

The aim of the study is to establish the validity of a patient reported diary in TN . The following objectives have been identified: 1. To generate evidence to support diary content validity by performing qualitative research studies with TN patients and Healthcare Professionals (HCPs). 2. To provide further support to the diary, sensitivity to change, known groups validity (ability to differentiate between severity groups), and construct validity.

NCT ID: NCT05914558 Active, not recruiting - Clinical trials for Temporomandibular Disorder

Comorbid Painful TMD Among Trigeminal Neuralgia

TNTMD
Start date: August 1, 2022
Phase:
Study type: Observational

An observational study following up with trigeminal neuralgia patients to understand their comorbid facial pain condition, specifically temporomandibular disorder.

NCT ID: NCT05810428 Recruiting - Virtual Reality Clinical Trials

Artificial Intelligence to Predict Surgical Outcomes and Assess Pain Neuromodulation in Trigeminal Neuralgia Subjects

Start date: April 6, 2023
Phase: N/A
Study type: Interventional

Trigeminal neuralgia (TN) is the most common cause of facial pain. Medical treatment is the first therapeutic choice whereas surgery, including Gamma Knife radiosurgery (GKRS), is indicated in case of pharmacological therapy failure. However, about 20% of subjects lack adequate pain relief after surgery. Virtual reality (VR) technology has been explored as a novel tool for reducing pain perception and might be the breakthrough in treatment-resistant cases. The investigators will conduct a prospective randomized comparative study to detect the effectiveness of GKRS aided by VR-training vs GKRS alone in TN patients. In addition, using MRI and artificial intelligence (AI), the investigators will identify pre-treatment abnormalities of central nervous system circuits associated with pain to predict response to treatment. The investigators expect that brain-based biomarkers, with clinical features, will provide key information in the personalization of treatment options and bring a huge impact in the management and understanding of pain in TN.