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Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression

Treatment Resistant Depression Clinical Trial

Official title:
Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression

Clinical Trial Summary

This study will investigate the anti-anhedonic efficacy of a novel neurostimulation strategy termed accelerated intermittent theta burst stimulation (aiTBS) in participants with treatment resistant depression (TRD).

Clinical Trial Description

Repetitive transcranial magnetic stimulation (rTMS) is an established therapy for treatment-resistant depression. The approved method for treatment is 10Hz stimulation for 40 min over the left dorsolateral prefrontal cortex (L-DLPFC). This methodology has been effective in real world situations. The limitations of this approach include the duration of the treatment (approximately 40 minutes per treatment session, 5 days per week, for 4-8 weeks). Recently, the investigators have pursued modifying the treatment parameters to reduce treatment times with an accelerated treatment paradigm. This study aims to further study the accelerated protocol and examine changes in neuroimaging biomarkers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06052137
Study type Interventional
Source Stanford University
Contact Nick Bassano
Phone 650-736-2233
Email nbassano@stanford.edu
Status Not yet recruiting
Phase N/A
Start date December 2023
Completion date October 2024
View Details
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